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Details on Person UniProt:F5HF68 vIRF-1
| Class:Id | ReferenceGeneProduct:9973231 |
|---|---|
| _chainChangeLog | chain:1-449 for 9973231 added on Fri Feb 20 2026 |
| _displayName | UniProt:F5HF68 vIRF-1 |
| _timestamp | 2026-02-20 23:01:46 |
| chain | chain:1-449 |
| checksum | 3C6A4E48FD57521A |
| comment | FUNCTION Plays a role in the inhibition of host innate response by repressing the expression of interferon-inducible genes and blocking host IRF1- and IRF3-mediated transcription. Blocks the interaction between host IRF3 and CREBBP. Regulates the host cellular metabolism by increasing glucose uptake, ATP production and lactate secretion through down-regulation of heterogeneous nuclear ribonuclear protein Q1/SYNCRIP. Mechanistically, induces ubiquitination and degradation of SYNCRIP through the ubiquitin-proteasome pathway by recruiting KLHL3/CUL3 ubiquitin ligase complex (PubMed:35538151). Disrupts host TP53 signaling pathway during viral infection by interacting with host USP7 and thereby decreasing the availability of USP7 for deubiquitinating and stabilizing TP53 (PubMed:26786098). Plays a role in the global inhibition of protein ISGylation by interacting with host HERC5 leading to its inhibition (PubMed:26355087). Promotes its own propionylation by blocking SIRT6 interaction with ubiquitin-specific peptidase 10/USP10 leading to SIRT6 degradation via a ubiquitin-proteasome pathway (PubMed:37023208). In turn, propionylation is required to block IRF3-CBP/p300 recruitment and to repress the STING DNA sensing pathway (PubMed:37023208). Plays a role in the activation of mitophagy during infection via interaction with the host proteins NIX/BNIP3L, TUFM and GABARAPL1 thereby inhibiting antiviral responses and contributing to productive replication (PubMed:31324791, PubMed:37459327).SUBUNIT Forms homodimers (PubMed:37459327). Interacts with host IRF3, IRF7, and CREBBP (PubMed:11314014). Interacts with host SYNCRIP (PubMed:35538151). Interacts with host USP7 (PubMed:26786098). Interacts (via C-terminus) with host HERC5 (PubMed:26355087). Interacts with host GABARAPL1 (PubMed:37459327). Interacts with host SIRT6 (PubMed:37023208).SUBCELLULAR LOCATION ISGylated.PTM Propionylated in lysine residues Lys-406 and Lys-442, which is required for effective inhibition of IFN-beta production and antiviral signaling.SIMILARITY Belongs to the IRF family. |
| created | [InstanceEdit:9973335] Orlic-Milacic, Marija, 2025-11-14 |
| description | recommendedName: VIRF-1 |
| geneName | vIRF-1 |
| identifier | F5HF68 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Host cytoplasm Host-virus interaction Inhibition of host innate immune response by virus Inhibition of host IRF3 by virus Inhibition of host RLR pathway by virus Reference proteome Ubl conjugation Viral immunoevasion |
| modified | [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | vIRF-1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | VIRF1_HHV8P |
| sequenceLength | 449 |
| species | [Species:2671781] Human herpesvirus 8 |
| (referenceEntity) | [EntityWithAccessionedSequence:9973192] vIRF-1 [cytosol] [Human herpesvirus 8] [EntityWithAccessionedSequence:9980147] Pr-K406,K442-vIRF-1 [cytosol] [Human herpesvirus 8] |
| (referenceSequence) | [ModifiedResidue:9980140] N6-propanoyl-L-lysine at 442 [ModifiedResidue:9980143] N6-propanoyl-L-lysine at 406 |
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No pathways have been reviewed or authored by UniProt:F5HF68 vIRF-1 (9973231)
