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Details on Person UniProt:F5HHY1 ORF38
| Class:Id | ReferenceGeneProduct:9973227 |
|---|---|
| _chainChangeLog | initiator methionine:1 for 9973227 added on Fri Feb 20 2026;chain:2-61 for 9973227 added on Fri Feb 20 2026 |
| _displayName | UniProt:F5HHY1 ORF38 |
| _timestamp | 2026-02-20 22:07:53 |
| chain | initiator methionine:1 chain:2-61 |
| checksum | 78AB187E8CC6DF7D |
| comment | FUNCTION Plays an important role in the cytoplasmic envelopment of tegument proteins and capsids during the assembly and egress processes. Also participates in viral entry at the fusion step probably by regulating the core fusion machinery.SUBUNIT Interacts with cytoplasmic envelopment protein 2; this interaction is essential for the proper localization of each protein to the assembly complex and thus for the production of infectious virus.SUBCELLULAR LOCATION Virion membrane-associated tegument protein. Associates with host membrane lipids rafts. During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).PTM Myristoylation and palmitoylation (probably on one or more of the nearby cysteines at the N-terminus) enable membrane-binding and Golgi apparatus-specific targeting and are essential for efficient packaging.PTM Phosphorylated. Phosphorylation does not seem to be required for recycling to the host Golgi apparatus. Packaging is selective for underphosphorylated forms.SIMILARITY Belongs to the herpesviridae cytoplasmic envelopment protein 3 family. |
| created | [InstanceEdit:9973335] Orlic-Milacic, Marija, 2025-11-14 |
| description | recommendedName: fullName evidence="1"Cytoplasmic envelopment protein 3 |
| geneName | ORF38 |
| identifier | F5HHY1 |
| isSequenceChanged | FALSE |
| keyword | Host cell membrane Host Golgi apparatus Host membrane Lipoprotein Membrane Myristate Palmitate Phosphoprotein Reference proteome Virion Virion tegument |
| modified | [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | ORF38 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | CEP3_HHV8P |
| sequenceLength | 61 |
| species | [Species:2671781] Human herpesvirus 8 |
| (referenceEntity) | [EntityWithAccessionedSequence:9973204] ORF38 [viral tegument] [Human herpesvirus 8] [EntityWithAccessionedSequence:9973285] ORF38 [cytosol] [Human herpesvirus 8] [EntityWithAccessionedSequence:9973329] ORF38 [endosome] [Human herpesvirus 8] [EntityWithAccessionedSequence:9973369] ORF38 [trans-Golgi network membrane] [Human herpesvirus 8] |
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No pathways have been reviewed or authored by UniProt:F5HHY1 ORF38 (9973227)
