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Details on Person UniProt:Q2HR73 vIRF-4
| Class:Id | ReferenceGeneProduct:9973209 |
|---|---|
| _chainChangeLog | chain:1-911 for 9973209 added on Fri Feb 20 2026 |
| _displayName | UniProt:Q2HR73 vIRF-4 |
| _timestamp | 2026-02-20 23:01:47 |
| chain | chain:1-911 |
| checksum | 0F82DA473774DC2D |
| comment | FUNCTION Plays a role in host cell apoptosis modulation by promoting TP53/p53 ubiquitination and subsequent degradation and thus down-regulating TP53/p53-mediated apoptosis (PubMed:19369353). Works as a potential viral transcription factor to modulate host gene expression to build favorable environments for the viral lytic life cycle and greatly accelerates the induction of an immediate early gene RTA, early genes ORF36 and ORF57, late genes ORF25 and ORF64, and latent genes LANA1 and v-IRF3 (PubMed:24335298). Inhibits host interferon-alpha production by interacting with host IRF7 and preventing IRF7 dimerization (PubMed:28342865).SUBUNIT Interacts with host MDM2; this interaction facilitates the proteasomal degradation of TP53/p53 (PubMed:19369353). Interacts with host IRF7; this interaction prevents IRF7 dimerization and subsequent activation (PubMed:28342865).INTERACTION Belongs to the IRF family. |
| created | [InstanceEdit:9973335] Orlic-Milacic, Marija, 2025-11-14 |
| description | recommendedName: Viral IRF4-like protein shortName: vIRF-4 |
| geneName | vIRF-4 |
| identifier | Q2HR73 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure DNA-binding Host nucleus Host-virus interaction Inhibition of host innate immune response by virus Inhibition of host IRF7 by virus Inhibition of host RLR pathway by virus Reference proteome Transcription Transcription regulation Viral immunoevasion |
| modified | [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | vIRF-4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | VIRF4_HHV8P D0UZS2 |
| sequenceLength | 911 |
| species | [Species:2671781] Human herpesvirus 8 |
| (referenceEntity) | [EntityWithAccessionedSequence:9973181] GlcNAc-vIRF-4 [nucleoplasm] [Human herpesvirus 8] [EntityWithAccessionedSequence:9979621] OGlcNAc-vIRF-4 [cytosol] [Human herpesvirus 8] [EntityWithAccessionedSequence:9979623] vIRF-4 [cytosol] [Human herpesvirus 8] |
| (referenceSequence) | [GroupModifiedResidue:9979624] O-glycosylated residue (O-(N-acetyl-β-D-glucosaminyl) residue) at unknown position |
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No pathways have been reviewed or authored by UniProt:Q2HR73 vIRF-4 (9973209)
