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Details on Person UniProt:Q2HRB4 ORF18
| Class:Id | ReferenceGeneProduct:9973202 |
|---|---|
| _chainChangeLog | chain:1-257 for 9973202 added on Fri Feb 20 2026 |
| _displayName | UniProt:Q2HRB4 ORF18 |
| _timestamp | 2026-02-20 22:05:30 |
| chain | chain:1-257 |
| checksum | 19247889069DEC87 |
| comment | FUNCTION Plays a role in the expression of late transcripts bridging viral DNA replication and late gene expression during infection.SUBUNIT Interacts with ORF30 (PubMed:25056896, PubMed:30305361). Interacts with ORF34 (PubMed:28336944).SUBCELLULAR LOCATION Localizes in replication compartments during virus infection.DISRUPTION PHENOTYPE Lytic replication is able to proceed normally with the expression of immediate-early and early genes as well as viral lytic DNA synthesis, but expression of viral late genes is severely impaired resulting in no detectable virion production.SIMILARITY Belongs to the herpesviridae UL79 family. |
| created | [InstanceEdit:9973335] Orlic-Milacic, Marija, 2025-11-14 |
| description | recommendedName: Protein UL79 homolog |
| geneName | ORF18 |
| identifier | Q2HRB4 |
| isSequenceChanged | FALSE |
| keyword | Host cytoplasm Host nucleus Reference proteome |
| modified | [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | ORF18 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | UL79_HHV8P |
| sequenceLength | 257 |
| species | [Species:2671781] Human herpesvirus 8 |
| (referenceEntity) | [EntityWithAccessionedSequence:9973210] ORF18 [nucleoplasm] [Human herpesvirus 8] [EntityWithAccessionedSequence:9973359] ORF18 [cytosol] [Human herpesvirus 8] |
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No pathways have been reviewed or authored by UniProt:Q2HRB4 ORF18 (9973202)
