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Details on Person UniProt:Q2HR82 K8
| Class:Id | ReferenceGeneProduct:9973190 |
|---|---|
| _chainChangeLog | chain:1-286 for 9973190 added on Fri Feb 20 2026 |
| _displayName | UniProt:Q2HR82 K8 |
| _timestamp | 2026-02-20 22:00:20 |
| chain | chain:1-286 |
| checksum | 69FE9D78A4BB4FEC |
| comment | FUNCTION SUMO E3 ligase that plays a role in viral gene regulation and is essential for viral reactivation (PubMed:17652396, PubMed:20034935). Disrupts host G1 cell cycle control thus allowing viral transcription and translation to proceed at the early stages of infection. Catalyzes its own SUMO modification as well as that of its interacting partners such as host TP53 and RB1. Regulates viral gene expression and reactivation and may mediate the SUMOylation of viral promoters in the low methylated 'Lys-9' histone H3 (H3K9me) region which results in a diminution of viral gene expression after reactivation (PubMed:26197391). SUMOylates also host histone lysine demethylase 4A/KDM4A, an essential step for complete enrichment of SUMO-2/3 on the viral genome during viral transactivation and reactivation (PubMed:28212444).PATHWAY Protein modification; protein sumoylation.SUBUNIT Interacts with host HDAC1 and HDAC2, these interactions suppress HDAC activities. Interacts with protein ORF57. Interacts with protein vPK (PubMed:17108053).INTERACTION Sumoylated. |
| created | [InstanceEdit:9973335] Orlic-Milacic, Marija, 2025-11-14 |
| description | recommendedName: fullName evidence="10"E3 SUMO-protein ligase K-bZIP ecNumber evidence="8"2.3.2.- alternativeName: fullName evidence="11"E3 SUMO-protein transferase K-bZIP |
| geneName | K8 |
| identifier | Q2HR82 |
| isSequenceChanged | FALSE |
| keyword | G1/S host cell cycle checkpoint dysregulation by virus Host-virus interaction Modulation of host cell cycle by virus Reference proteome Transferase Ubl conjugation Ubl conjugation pathway |
| modified | [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | K8 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | KBZIP_HHV8P |
| sequenceLength | 286 |
| species | [Species:2671781] Human herpesvirus 8 |
| (referenceEntity) | [EntityWithAccessionedSequence:9973276] K8 [nucleoplasm] [Human herpesvirus 8] [EntityWithAccessionedSequence:9978154] OGlcNAc-K8 [cytosol] [Human herpesvirus 8] [EntityWithAccessionedSequence:9978155] K8 [cytosol] [Human herpesvirus 8] [EntityWithAccessionedSequence:9978194] OGlcNAc-K8 [nucleoplasm] [Human herpesvirus 8] [EntityWithAccessionedSequence:9978215] polySUMO2,3-K158-OGlcNAc-K8 [nucleoplasm] [Human herpesvirus 8] [EntityWithAccessionedSequence:9978300] p-T111,S167-OGlcNAc-K8 [nucleoplasm] [Human herpesvirus 8] [EntityWithAccessionedSequence:9978808] p-T111-OGlcNAc-K8 [nucleoplasm] [Human herpesvirus 8] |
| (referenceSequence) | [GroupModifiedResidue:9978151] O-glycosylated residue (O-(N-acetyl-β-D-glucosaminyl) residue) at unknown position [GroupModifiedResidue:9978222] sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 158 [ModifiedResidue:9978292] O-phospho-L-serine at 167 [ModifiedResidue:9978308] O-phospho-L-threonine at 111 |
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No pathways have been reviewed or authored by UniProt:Q2HR82 K8 (9973190)
