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Details on Person UniProt:Q2HRD4 ORF4
| Class:Id | ReferenceGeneProduct:9973186 |
|---|---|
| _chainChangeLog | signal peptide:1-19 for 9973186 added on Fri Feb 20 2026;chain:20-550 for 9973186 added on Fri Feb 20 2026 |
| _displayName | UniProt:Q2HRD4 ORF4 |
| _timestamp | 2026-02-20 22:25:00 |
| chain | signal peptide:1-19 chain:20-550 |
| checksum | 068FC1C30ADDDE32 |
| comment | FUNCTION Inhibits the complement component of the host innate immune response. Regulates host C3 convertases, accelerating their decay, and acts as a cofactor for factor I degradation of C4b and C3b. Also binds heparin, and therefore may play two distinct roles when incorporated in virion membranes: immune evasion and host cell binding. |
| created | [InstanceEdit:9973335] Orlic-Milacic, Marija, 2025-11-14 |
| description | recommendedName: Complement control protein shortName: KCP |
| geneName | ORF4 |
| identifier | Q2HRD4 |
| isSequenceChanged | FALSE |
| keyword | Disulfide bond Glycoprotein Host membrane Host-virus interaction Inhibition of host complement factors by virus Membrane Reference proteome Repeat Signal Sushi Transmembrane Transmembrane helix Viral immunoevasion Virion |
| modified | [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | ORF4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | ORF4_HHV8P D0UZL0 |
| sequenceLength | 550 |
| species | [Species:2671781] Human herpesvirus 8 |
| (referenceEntity) | [EntityWithAccessionedSequence:9973194] ORF4 [virion membrane] [Human herpesvirus 8] [EntityWithAccessionedSequence:9973252] GlcNAc-ORF4 [plasma membrane] [Human herpesvirus 8] [EntityWithAccessionedSequence:9979231] GlcNAc-ORF4 [trans-Golgi network membrane] [Human herpesvirus 8] [EntityWithAccessionedSequence:9979237] ORF4 [endoplasmic reticulum membrane] [Human herpesvirus 8] [EntityWithAccessionedSequence:9987208] GlcNAc-ORF4 [viral envelope] [Human herpesvirus 8] |
| (referenceSequence) | [GroupModifiedResidue:9979242] N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at unknown position |
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No pathways have been reviewed or authored by UniProt:Q2HRD4 ORF4 (9973186)
