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Details on Person Dephosphorylation of JAK1 by SHP1

Class:Id	Reaction:997314
_displayName	Dephosphorylation of JAK1 by SHP1
_doRelease	TRUE
_timestamp	2017-12-22 15:24:00
authored	[InstanceEdit:909728] Garapati, P V, 2010-07-07
catalystActivity	[CatalystActivity:392414] protein tyrosine phosphatase activity of PTPN6 [cytosol]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:997324] Garapati, P V, 2010-11-08
edited	[InstanceEdit:909728] Garapati, P V, 2010-07-07
input	[SimpleEntity:29356] H2O [cytosol] [Complex:997300] IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:877305] Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1 [LiteratureReference:997317] Protein tyrosine phosphatases in the JAK/STAT pathway
modified	[InstanceEdit:998146] Garapati, P V, 2010-11-09 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9033585] Orlic-Milacic, Marija, 2017-12-22 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Dephosphorylation of JAK1 by SHP1
output	[Complex:909703] IFNA/B:IFNAR2:JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] [Homo sapiens] [SimpleEntity:29372] Pi [cytosol]
precedingEvent	[Reaction:997311] Dephosphorylation of TYK2 by PTP1B [Homo sapiens] [Reaction:909729] Activation of JAK kinases [Homo sapiens]
releaseDate	2010-12-14
reviewed	[InstanceEdit:933762] Abdul-Sater, AA, Schindler, C, 2010-08-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105488] R-HSA-997314.3
summation	[Summation:997287] SHP1 directly associates with and dephosphorylates JAK1/2.
(hasEvent)	[Pathway:912694] Regulation of IFNA/IFNB signaling [Homo sapiens]
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No pathways have been reviewed or authored by Dephosphorylation of JAK1 by SHP1 (997314)