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Details on Person Formation of RV-A single-layered particles

Class:Id	Reaction:9973110
_displayName	Formation of RV-A single-layered particles
_doRelease	FALSE
_timestamp	2026-01-21 15:42:35
authored	[InstanceEdit:9979788] Orlic-Milacic, Marija, 2026-01-21
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9973143] Orlic-Milacic, Marija, 2025-11-14
disease	[Disease:3134794] viral infectious disease
input	[Complex:9964328] RV-A VP7 dsRNA:RTC [cytosol] [Rotavirus A] [Complex:9964319] RV-A NSP4 dsRNA:RTC [cytosol] [Rotavirus A] [Complex:9964330] RV-A NSP1 dsRNA:RTC [cytosol] [Rotavirus A] [Complex:9964338] RV-A NSP2 dsRNA:RTC [cytosol] [Rotavirus A] [Complex:9964342] RV-A NSP3 dsRNA:RTC [cytosol] [Rotavirus A] [Complex:9964320] RV-A NSP5/6 dsRNA:RTC [cytosol] [Rotavirus A] [Complex:9964333] RV-A VP1 dsRNA:RTC [cytosol] [Rotavirus A] [Complex:9964340] RV-A VP2 dsRNA:RTC [cytosol] [Rotavirus A] [Complex:9964336] RV-A VP3 dsRNA:RTC [cytosol] [Rotavirus A] [Complex:9964337] RV-A VP4 dsRNA:RTC [cytosol] [Rotavirus A] [Complex:9964322] RV-A VP6 dsRNA:RTC [cytosol] [Rotavirus A] [Complex:9960975] RV-A RTC [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9821179] In situ Structure of Rotavirus VP1 RNA-Dependent RNA Polymerase [LiteratureReference:9973834] Location of the dsRNA-dependent polymerase, VP1, in rotavirus particles
modified	[InstanceEdit:9973835] Orlic-Milacic, Marija, 2025-11-17 [InstanceEdit:9977070] Orlic-Milacic, Marija, 2025-12-16 [InstanceEdit:9979789] Orlic-Milacic, Marija, 2026-01-21
name	Formation of RV-A single-layered particles
output	[Complex:9964367] RV-A virion single layer particle (core) [cytosol] [Rotavirus A]
precedingEvent	[Reaction:9960589] Formation of RV-A transcription complex (RV-A TC) [Homo sapiens] [BlackBoxEvent:9965293] Translation of RV-A VP1 [Homo sapiens] [BlackBoxEvent:9821148] VP2 forms a decamer [Homo sapiens] [Reaction:9821170] VP3 forms a tetramer [Homo sapiens] [BlackBoxEvent:9966047] Replication of RV-A [Homo sapiens] [Reaction:9973136] Capped +ssRNA binds RV-A replication and transcription complex [Homo sapiens]
regulatedBy	[PositiveRegulation:9977066] Positive regulation by 'pp-NSP5:p-NSP2:p-PLIN1 [cytosol]'
relatedSpecies	[Species:9615053] Rotavirus A
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9973155] R-HSA-9973110.1
structureModified	[InstanceEdit:9977070] Orlic-Milacic, Marija, 2025-12-16
summation	[Summation:9973134] Single-layer particles of rotavirus A (RV-A) consist of t...
(hasEvent)	[Pathway:9819331] Genome Replication, Assembly and Release of Rotavirus A (RV-A) triple-layer particles (TLPs) [Homo sapiens]
(precedingEvent)	[Reaction:9973104] Formation of RV-A double-layered particle (DLP) [Homo sapiens]
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No pathways have been reviewed or authored by Formation of RV-A single-layered particles (9973110)