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Details on Person Dephosphorylation of STAT1 by SHP2

Class:Id	Reaction:997309
_displayName	Dephosphorylation of STAT1 by SHP2
_doRelease	TRUE
_timestamp	2017-12-22 18:54:27
authored	[InstanceEdit:909728] Garapati, P V, 2010-07-07
catalystActivity	[CatalystActivity:210262] protein tyrosine phosphatase activity of PTPN11 [cytosol]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:997324] Garapati, P V, 2010-11-08
edited	[InstanceEdit:909728] Garapati, P V, 2010-07-07
input	[Complex:909711] IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:p-STAT1 [plasma membrane] [Homo sapiens] [SimpleEntity:29356] H2O [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:912699] Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway [LiteratureReference:997317] Protein tyrosine phosphatases in the JAK/STAT pathway
modified	[InstanceEdit:998146] Garapati, P V, 2010-11-09 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9033594] Orlic-Milacic, Marija, 2017-12-22 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Dephosphorylation of STAT1 by SHP2
output	[Complex:997304] IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:STAT1 [plasma membrane] [Homo sapiens] [SimpleEntity:29372] Pi [cytosol]
precedingEvent	[Reaction:909726] Phosphorylation of STAT1 [Homo sapiens] [Reaction:909732] Phosphorylation of STAT2 [Homo sapiens]
releaseDate	2010-12-14
reviewed	[InstanceEdit:933762] Abdul-Sater, AA, Schindler, C, 2010-08-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104153] R-HSA-997309.3
summation	[Summation:997285] SHP2 negatively regulates the IFN-induced JAK-STAT pathway b...
(hasEvent)	[Pathway:912694] Regulation of IFNA/IFNB signaling [Homo sapiens]
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No pathways have been reviewed or authored by Dephosphorylation of STAT1 by SHP2 (997309)