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Details on Person Based on mouse findings, RNF220, an E3 ubiquitin ligase, med...
| Class:Id | Summation:9973063 |
|---|---|
| _displayName | Based on mouse findings, RNF220, an E3 ubiquitin ligase, med... |
| _timestamp | 2025-11-14 12:42:41 |
| created | [InstanceEdit:9973078] Orlic-Milacic, Marija, 2025-11-14 |
| text | Based on mouse findings, RNF220, an E3 ubiquitin ligase, mediates K63-linked polyubiquitination of OLIG2, leading to OLIG2 protein stabilization and increased OLIG2 transcriptional activity (Li et al. 2024). Two lysine residues of Olig2 polyubiquitinated by Rnf220, K69 and K262 (Li et al. 2024), are conserved in human OLIG2 and correspond to residues K69 and K262 (identical positions as in mouse Olig2), respectively. Based on the UniProt Align tool, human and mouse OLIG2 share 96% amino acid sequence identity while human and mouse RNF220 share 98% amino acid sequence identity. |
| (summation) | [Reaction:9973030] RNF220 mediates K63-linked polyubiquitination of OLIG2 [Homo sapiens] |
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No pathways have been reviewed or authored by Based on mouse findings, RNF220, an E3 ubiquitin ligase, med... (9973063)
