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Details on Person AADAT transaminates 3HKYN to xanthurenate

Class:Id	Reaction:9972889
_displayName	AADAT transaminates 3HKYN to xanthurenate
_doRelease	TRUE
_timestamp	2026-03-09 08:25:40
authored	[InstanceEdit:9972903] Stephan, Ralf, 2025-11-12
catalystActivity	[CatalystActivity:9972882] transaminase activity of AADAT dimer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9972892] Stephan, Ralf, 2025-11-14
crossReference	[DatabaseIdentifier:9972894] RHEA:65901
edited	[InstanceEdit:9984514] Stephan, Ralf, 2026-03-09
input	[SimpleEntity:34351] 3HKYN [cytosol] [SimpleEntity:5367039] glyoxylate [cytosol]
internalReviewed	[InstanceEdit:9973615] D'Eustachio, Peter, 2025-11-14
isChimeric	FALSE
literatureReference	[LiteratureReference:9972901] Substrate specificity and structure of human aminoadipate aminotransferase/kynurenine aminotransferase II [LiteratureReference:9972883] Xanthurenic Acid Formation from 3-Hydroxykynurenine in the Mammalian Brain: Neurochemical Characterization and Physiological Effects [LiteratureReference:9972886] Demonstration of kynurenine aminotransferases I and II and characterization of kynurenic acid synthesis in cultured cerebral cortical neurons
modified	[InstanceEdit:9973616] D'Eustachio, Peter, 2025-11-14 [InstanceEdit:9981793] D'Eustachio, Peter, 2026-02-10 [InstanceEdit:9983643] Stephan, Ralf, 2026-02-25 [InstanceEdit:9983941] Stephan, Ralf, 2026-03-02 [InstanceEdit:9984515] Stephan, Ralf, 2026-03-09
name	AADAT transaminates 3HKYN to xanthurenate 3-hydroxy-L-kynurenine + glyoxylate => xanthurenate + glycine + H2O
output	[SimpleEntity:9972885] xanthurenate [cytosol] [SimpleEntity:29424] Gly [cytosol] [SimpleEntity:29356] H2O [cytosol]
precedingEvent	[Reaction:71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O [Homo sapiens] [Reaction:71189] AFMID hydrolyses NFK to L-KYN [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2026-03-25
reviewed	[InstanceEdit:9981792] D'Eustachio, Peter, 2026-02-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9972908] R-HSA-9972889.1
summation	[Summation:9972896] Kynurenine/alpha-aminoadipate aminotransferase (AADAT, KAT I...
(hasEvent)	[Pathway:71240] Tryptophan catabolism [Homo sapiens]
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No pathways have been reviewed or authored by AADAT transaminates 3HKYN to xanthurenate (9972889)