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Details on Person The SH2B family has 3 members sharing a common domain struct...

Class:IdSummation:997260
_displayNameThe SH2B family has 3 members sharing a common domain struct...
_timestamp2010-11-17 17:14:27
created[InstanceEdit:997250] Jupe, S, 2010-11-08
literatureReference[LiteratureReference:997236] Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2
[LiteratureReference:997244] Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta
[LiteratureReference:997257] Binding of SH2-B family members within a potential negative regulatory region maintains JAK2 in an active state
[LiteratureReference:997246] Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617F
[LiteratureReference:1027319] Thrombopoietin and its receptor
modified[InstanceEdit:1008204] Jupe, S, 2010-11-10
[InstanceEdit:1027306] Jupe, S, 2010-11-17
textThe SH2B family has 3 members sharing a common domain structure, including a dimerization domain, a pleckstrin homology (PH) region, and a SH2 domain. The SH2 domain binds phosphotyrosines of various signal-transducing proteins such as c-Kit, MPL, EpoR. All are able to bind JAK2 phosphorylated at Tyr-813 (Bersenev et al. 2008, Kurzer et al. 2004, 2006), inhibiting JAK2 proliferative signaling (Gery et al. 2009).
(summation)[Reaction:997237] SH2B proteins bind JAK2 [Homo sapiens]
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