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Details on Person Repertoire Sequencing of B Cells Elucidates the Role of UNG and Mismatch Repair Proteins in Somatic Hypermutation in Humans
| Class:Id | LiteratureReference:9971688 |
| _displayName | Repertoire Sequencing of B Cells Elucidates the Role of UNG and Mismatch Repair Proteins in Somatic Hypermutation in Humans |
| _timestamp | 2025-11-10 07:51:57 |
| author | [Person:9971678] IJspeert, Hanna [Person:9971689] van Schouwenburg, Pauline A [Person:9971674] Pico-Knijnenburg, Ingrid [Person:9971691] Loeffen, Jan [Person:9676754] Brugières, Laurence [Person:9971666] Driessen, Gertjan J [Person:9971685] Blattmann, Claudia [Person:9971670] Suerink, Manon [Person:9971673] Januszkiewicz-Lewandowska, Danuta [Person:9971680] Azizi, Amedeo A [Person:9971671] Seidel, Marcus G [Person:9947319] Jacobs, Heinz [Person:9971667] van der Burg, Mirjam |
| created | [InstanceEdit:9971668] May, Bruce, 2025-11-10 |
| journal | Front Immunol |
| pages | 1913 |
| pubMedIdentifier | 31507588 |
| title | Repertoire Sequencing of B Cells Elucidates the Role of UNG and Mismatch Repair Proteins in Somatic Hypermutation in Humans |
| volume | 10 |
| year | 2019 |
| (literatureReference) | [Reaction:9943321] UNG hydrolyzes 2'-deoxyuridine in DNA yielding an abasic site [Homo sapiens] [Pathway:9968295] Somatic hypermutation of immunoglobulin genes by error-prone mismatch repair (MMR) [Homo sapiens] [Reaction:9968296] MLH1:PMS2 makes a single-stranded nick near U:G mismatch [Homo sapiens] [Pathway:9968297] Somatic hypermutation of immunoglobulin genes by error-prone base excision repair (BER) [Homo sapiens] [Reaction:9968300] MSH2:MSH6 bound to U:G mismatch exchanges ADP for ATP [Homo sapiens] [Reaction:9968305] MSH2:MSH6:ADP binds U:G mismatch in dsDNA [Homo sapiens] [Reaction:9968306] MSH2:MSH6:ATP bound to U:G mismatch binds MLH1:PMS2 [Homo sapiens] |
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