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Details on Person The MSH2:MSH6 (MutSalpha) heterodimer binds single base mism...
| Class:Id | Summation:9971683 |
|---|---|
| _displayName | The MSH2:MSH6 (MutSalpha) heterodimer binds single base mism... |
| _timestamp | 2026-04-26 21:24:18 |
| created | [InstanceEdit:9971668] May, Bruce, 2025-11-10 |
| literatureReference | [LiteratureReference:9971675] A role for Msh6 but not Msh3 in somatic hypermutation and class switch recombination [LiteratureReference:9971682] Somatic hypermutation and class switch recombination in Msh6(-/-)Ung(-/-) double-knockout mice [LiteratureReference:9971677] Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting [LiteratureReference:9973718] MSH2/MSH6 complex promotes error-free repair of AID-induced dU:G mispairs as well as error-prone hypermutation of A:T sites |
| modified | [InstanceEdit:9973671] May, Bruce, 2025-11-15 [InstanceEdit:9973698] May, Bruce, 2025-11-15 [InstanceEdit:9973733] May, Bruce, 2025-11-16 [InstanceEdit:9975295] May, Bruce, 2025-11-30 [InstanceEdit:9975347] May, Bruce, 2025-12-01 [InstanceEdit:9980002] May, Bruce, 2026-01-23 [InstanceEdit:9987697] May, Bruce, 2026-04-26 |
| text | The MSH2:MSH6 (MutSalpha) heterodimer binds single base mismatches and insertion or deletion loops (IDLs) of 1-2 bases (Drummond et al. 1997, Genschel et al. 1998, Gradia et al. 2000, Zhang et al. 2005, Constantin et al. 2005, Tian et al. 2009, reviewed in Edelbrock et al. 2013). MSH2:MSH6 binds G:U mismatches in vitro (Wilson et al. 2005) and, based on phenotypes of individuals lacking MSH2 or MSH6, MSH2:MSH6 is concluded to bind G:U mismatches produced by AICDA during somatic hypermutation (IJspeert et al. 2019). Analysis of the pattern of mutations in variable regions of heavy chain genes in human patients lacking MSH2 or MSH6 indicates that about 65% of mutations at A or T residues are due to mismatch repair (IJspeert et al. 2019). Error-prone base excision repair initiated by UNG is responsible for the remaining 35% (Ijspeert et al. 2019). Likewise, analysis of mutations at variable regions of immunoglobulin genes in mice lacking Msh2 (Frey et al. 1998, Rada et al. 1998) or Msh6 (Martomo et al. 2004, Shen et al. 2006) or both (Roa et al. 2010) indicate that single base mismatch repair by Msh2:Msh6 drives mutagenesis at A:T residues through error-prone repair. Inactivation of Msh3 had no effect, indicating that recognition of longer mismatches by Msh2:Msh3 plays no role in somatic hypermutation (Martomo et al. 2004). |
| (summation) | [Reaction:9968305] MSH2:MSH6:ADP binds U:G mismatch in dsDNA [Homo sapiens] |
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