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Details on Person PABPN1-stimulated PAPOL synthesizes polyA tail at intronic PAS

Class:Id	BlackBoxEvent:9970320
_displayName	PABPN1-stimulated PAPOL synthesizes polyA tail at intronic PAS
_doRelease	TRUE
_timestamp	2025-11-10 16:04:41
authored	[InstanceEdit:9770563] Ahluwalia, Rhea, 2025-10-01
catalystActivity	[CatalystActivity:9970400] poly(A) RNA polymerase activity of Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9970321] Orlic-Milacic, Marija, 2025-10-29
edited	[InstanceEdit:9971425] Orlic-Milacic, Marija, 2025-11-06
input	[Complex:9970296] Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] [Homo sapiens] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] 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[SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:72008] PABPN1 [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9971552] May, Bruce, 2025-11-07
isChimeric	FALSE
literatureReference	[LiteratureReference:9970842] Distinct regulation of alternative polyadenylation and gene expression by nuclear poly(A) polymerases [LiteratureReference:9971335] Molecular basis of human poly(A) polymerase recruitment by mPSF [LiteratureReference:9970841] A PtdIns4,5P2-regulated nuclear poly(A) polymerase controls expression of select mRNAs [LiteratureReference:9970840] Star-PAP control of BIK expression and apoptosis is regulated by nuclear PIPKIα and PKCδ signaling [LiteratureReference:9971340] The nuclear poly(A) binding protein of mammals, but not of fission yeast, participates in mRNA polyadenylation [LiteratureReference:9970843] Crystal structure of human poly(A) polymerase gamma reveals a conserved catalytic core for canonical poly(A) polymerases
modified	[InstanceEdit:9970409] Orlic-Milacic, Marija, 2025-10-29 [InstanceEdit:9970651] Orlic-Milacic, Marija, 2025-10-31 [InstanceEdit:9970852] Orlic-Milacic, Marija, 2025-11-03 [InstanceEdit:9971058] Orlic-Milacic, Marija, 2025-11-04 [InstanceEdit:9971059] Orlic-Milacic, Marija, 2025-11-04 [InstanceEdit:9971339] Orlic-Milacic, Marija, 2025-11-05 [InstanceEdit:9971406] Orlic-Milacic, Marija, 2025-11-05 [InstanceEdit:9971407] Orlic-Milacic, Marija, 2025-11-05 [InstanceEdit:9971426] Orlic-Milacic, Marija, 2025-11-06 [InstanceEdit:9971473] Orlic-Milacic, Marija, 2025-11-06 [InstanceEdit:9971582] Orlic-Milacic, Marija, 2025-11-07 [InstanceEdit:9971708] Orlic-Milacic, Marija, 2025-11-10 [InstanceEdit:9971715] Orlic-Milacic, Marija, 2025-11-10
name	PABPN1-stimulated PAPOL synthesizes polyA tail at intronic PAS
negativePrecedingEvent	[NegativePrecedingEvent:9971461] Futile Cycle: CPA complex components dissociate from polyadenylated pre-mRNA (distal 3'UTR PAS) [NegativePrecedingEvent:9971466] Futile Cycle: CPA complex components dissociate from polyadenylated pre-mRNA (intronic PAS) [NegativePrecedingEvent:9971471] Futile Cycle: CPA complex components dissociate from polyadenylated pre-mRNA (proximal 3'UTR PAS)
output	[SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi 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[nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [SimpleEntity:113541] PPi [nucleoplasm] [Complex:9970402] Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9970282] U1 snRNP suppresses CPSF3-mediated pre-mRNA cleavage at intronic PAS [Homo sapiens] [BlackBoxEvent:9970191] RBBP6 activates CPSF complex [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2025-12-08
reviewed	[InstanceEdit:9971707] Ahluwalia, Rhea, 2025-11-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9970335] R-HSA-9970320.1
structureModified	[InstanceEdit:9970409] Orlic-Milacic, Marija, 2025-10-29 [InstanceEdit:9971708] Orlic-Milacic, Marija, 2025-11-10
summation	[Summation:9970847] The 5' fragment generated by 3' cleavage of the pre-mRNA ...
(hasEvent)	[Pathway:9770562] mRNA Polyadenylation [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9970429] CPA complex components dissociate from polyadenylated pre-mRNA (intronic PAS) [Homo sapiens]
(replacementInstances)	[_Deleted:9971709] Deletion of instance: 72185
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No pathways have been reviewed or authored by PABPN1-stimulated PAPOL synthesizes polyA tail at intronic PAS (9970320)