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Details on Person CPSF3 cleaves pre-mRNA at distal 3'UTR PAS

Class:IdReaction:9970193
_displayNameCPSF3 cleaves pre-mRNA at distal 3'UTR PAS
_doReleaseTRUE
_timestamp2025-11-10 16:03:38
authored[InstanceEdit:72178] Wahle, E, 2003-06-05 08:30:31
[InstanceEdit:9770563] Ahluwalia, Rhea, 2025-10-01
catalystActivity[CatalystActivity:9970286] endonuclease activity of Ub-K63-CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser2 dephosphorylated) [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9970194] Orlic-Milacic, Marija, 2025-10-29
edited[InstanceEdit:9971425] Orlic-Milacic, Marija, 2025-11-06
input[Complex:9970269] Ub-K63-CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser2 dephosphorylated) [nucleoplasm] [Homo sapiens]
internalReviewed[InstanceEdit:9971552] May, Bruce, 2025-11-07
isChimericFALSE
literatureReference[LiteratureReference:9970604] Evidence that polyadenylation factor CPSF-73 is the mRNA 3' processing endonuclease
[LiteratureReference:9970609] Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease
[LiteratureReference:9970629] Genome-wide analysis of pre-mRNA 3' end processing reveals a decisive role of human cleavage factor I in the regulation of 3' UTR length
[LiteratureReference:9770874] Systematic profiling of poly(A)+ transcripts modulated by core 3' end processing and splicing factors reveals regulatory rules of alternative cleavage and polyadenylation
modified[InstanceEdit:9970317] Orlic-Milacic, Marija, 2025-10-29
[InstanceEdit:9970519] Orlic-Milacic, Marija, 2025-10-30
[InstanceEdit:9970552] Orlic-Milacic, Marija, 2025-10-30
[InstanceEdit:9970607] Orlic-Milacic, Marija, 2025-10-31
[InstanceEdit:9970613] Orlic-Milacic, Marija, 2025-10-31
[InstanceEdit:9970635] Orlic-Milacic, Marija, 2025-10-31
[InstanceEdit:9970651] Orlic-Milacic, Marija, 2025-10-31
[InstanceEdit:9971058] Orlic-Milacic, Marija, 2025-11-04
[InstanceEdit:9971059] Orlic-Milacic, Marija, 2025-11-04
[InstanceEdit:9971426] Orlic-Milacic, Marija, 2025-11-06
[InstanceEdit:9971473] Orlic-Milacic, Marija, 2025-11-06
[InstanceEdit:9971582] Orlic-Milacic, Marija, 2025-11-07
[InstanceEdit:9971712] Orlic-Milacic, Marija, 2025-11-10
nameCPSF3 cleaves pre-mRNA at distal 3'UTR PAS
negativePrecedingEvent[NegativePrecedingEvent:9971457] Futile Cycle: CPA complex components dissociate from polyadenylated pre-mRNA (distal 3'UTR PAS)
[NegativePrecedingEvent:9971458] Futile Cycle: CPA complex components dissociate from polyadenylated pre-mRNA (intronic PAS)
[NegativePrecedingEvent:9971469] Futile Cycle: CPA complex components dissociate from polyadenylated pre-mRNA (proximal 3'UTR PAS)
output[Complex:9970298] Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] [Homo sapiens]
[GenomeEncodedEntity:9971053] pre-mRNA 3' cleavage fragment [nucleoplasm] [Homo sapiens]
precedingEvent
regulatedBy[PositiveRegulation:9970551] Positive regulation by 'RBBP6 [nucleoplasm]'
[PositiveRegulation:9970632] Positive regulation by 'NUDT21 [nucleoplasm]'
[PositiveRegulation:9970633] Positive regulation by 'CPSF6-1 [nucleoplasm]'
releaseDate2025-12-08
reviewed[InstanceEdit:9971220] Ahluwalia, Rhea, 2025-11-10
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9970201] R-HSA-9970193.1
structureModified[InstanceEdit:9970317] Orlic-Milacic, Marija, 2025-10-29
[InstanceEdit:9970552] Orlic-Milacic, Marija, 2025-10-30
[InstanceEdit:9970635] Orlic-Milacic, Marija, 2025-10-31
[InstanceEdit:9971058] Orlic-Milacic, Marija, 2025-11-04
summation[Summation:9970517]

CPSF3 (also known as CPSF73) is the endonuclease that cle...

(hasEvent)[Pathway:9770562] mRNA Polyadenylation [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9970189] PABPN1-stimulated PAPOL synthesizes polyA tail at distal 3'UTR PAS [Homo sapiens]
[Reaction:9970195] PABPN1 is recruited to the growing polyA tail [Homo sapiens]
[BlackBoxEvent:9971054] XRN2 degrades downstream RNA fragment, promoting transcription termination [Homo sapiens]
(replacementInstances)[_Deleted:9984274] Deletion of instance: 72180
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No pathways have been reviewed or authored by CPSF3 cleaves pre-mRNA at distal 3'UTR PAS (9970193)
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