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Details on Person RBBP6 activates CPSF complex

Class:IdBlackBoxEvent:9970191
_displayNameRBBP6 activates CPSF complex
_doReleaseTRUE
_timestamp2025-11-07 16:30:28
authored[InstanceEdit:9971052] Ahluwalia, Rhea, 2025-10-01
catalystActivity[CatalystActivity:9970270] ubiquitin-protein transferase activity of CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9970194] Orlic-Milacic, Marija, 2025-10-29
edited[InstanceEdit:9971425] Orlic-Milacic, Marija, 2025-11-06
input[Complex:9970254] CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] [Homo sapiens]
[DefinedSet:6782535] K63-Ub [nucleoplasm] [Homo sapiens]
internalReviewed[InstanceEdit:9971552] May, Bruce, 2025-11-07
isChimericFALSE
literatureReference[LiteratureReference:9970561] RBBP6 activates the pre-mRNA 3' end processing machinery in humans
[LiteratureReference:9970244] Reconstitution of 3' end processing of mammalian pre-mRNA reveals a central role of RBBP6
[LiteratureReference:9970562] RBBP6 maintains glioblastoma stem cells through CPSF3-dependent alternative polyadenylation
modified[InstanceEdit:9970280] Orlic-Milacic, Marija, 2025-10-29
[InstanceEdit:9970572] Orlic-Milacic, Marija, 2025-10-30
[InstanceEdit:9970651] Orlic-Milacic, Marija, 2025-10-31
[InstanceEdit:9971058] Orlic-Milacic, Marija, 2025-11-04
[InstanceEdit:9971059] Orlic-Milacic, Marija, 2025-11-04
[InstanceEdit:9971426] Orlic-Milacic, Marija, 2025-11-06
[InstanceEdit:9971582] Orlic-Milacic, Marija, 2025-11-07
nameRBBP6 activates CPSF complex
output[Complex:9970269] Ub-K63-CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser2 dephosphorylated) [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate2025-12-08
reviewed[InstanceEdit:9971220] Ahluwalia, Rhea, 2025-11-10
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9970199] R-HSA-9970191.1
structureModified[InstanceEdit:9970280] Orlic-Milacic, Marija, 2025-10-29
summation[Summation:9970570]

RBBP6 activates the endonuclease activity of CPSF3, a com...

(hasEvent)[Pathway:9770562] mRNA Polyadenylation [Homo sapiens]
(precedingEvent)[Reaction:9970193] CPSF3 cleaves pre-mRNA at distal 3'UTR PAS [Homo sapiens]
[Reaction:9970282] U1 snRNP suppresses CPSF3-mediated pre-mRNA cleavage at intronic PAS [Homo sapiens]
[Reaction:9970294] CPSF3 cleaves pre-mRNA at proximal 3'UTR PAS [Homo sapiens]
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No pathways have been reviewed or authored by RBBP6 activates CPSF complex (9970191)
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