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Details on Person Recruitment of other CPA components to pre-mRNA-bound CPA core

Class:Id	Reaction:9970179
_displayName	Recruitment of other CPA components to pre-mRNA-bound CPA core
_doRelease	TRUE
_timestamp	2025-11-10 16:25:28
authored	[InstanceEdit:72178] Wahle, E, 2003-06-05 08:30:31 [InstanceEdit:9770563] Ahluwalia, Rhea, 2025-10-01
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9970177] Orlic-Milacic, Marija, 2025-10-29
edited	[InstanceEdit:9971425] Orlic-Milacic, Marija, 2025-11-06
input	[Complex:9970140] Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] [Homo sapiens] [Complex:72020] CF II [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9970176] RBBP6 [nucleoplasm] [Homo sapiens] [Complex:9970180] PP1:PPP1R10 [nucleoplasm] [Homo sapiens] [DefinedSet:9970174] PAPOLA, PAPOLG, TUT1 [nucleoplasm] [Homo sapiens] [SimpleEntity:29358] ATP [nucleoplasm]
internalReviewed	[InstanceEdit:9971552] May, Bruce, 2025-11-07
isChimeric	FALSE
literatureReference	[LiteratureReference:8938798] Molecular architecture of the human pre-mRNA 3' processing complex [LiteratureReference:9970236] Overlapping and distinct functions of SPT6, PNUTS, and PCF11 in regulating transcription termination [LiteratureReference:9770688] Reconstitution of mammalian cleavage factor II involved in 3' processing of mRNA precursors [LiteratureReference:9970244] Reconstitution of 3' end processing of mammalian pre-mRNA reveals a central role of RBBP6 [LiteratureReference:9970546] RBBP6 isoforms regulate the human polyadenylation machinery and modulate expression of mRNAs with AU-rich 3' UTRs [LiteratureReference:9970561] RBBP6 activates the pre-mRNA 3' end processing machinery in humans [LiteratureReference:9970841] A PtdIns4,5P2-regulated nuclear poly(A) polymerase controls expression of select mRNAs [LiteratureReference:9970840] Star-PAP control of BIK expression and apoptosis is regulated by nuclear PIPKIα and PKCδ signaling [LiteratureReference:9970843] Crystal structure of human poly(A) polymerase gamma reveals a conserved catalytic core for canonical poly(A) polymerases [LiteratureReference:9970842] Distinct regulation of alternative polyadenylation and gene expression by nuclear poly(A) polymerases
modified	[InstanceEdit:9970214] Orlic-Milacic, Marija, 2025-10-29 [InstanceEdit:9970251] Orlic-Milacic, Marija, 2025-10-29 [InstanceEdit:9970549] Orlic-Milacic, Marija, 2025-10-30 [InstanceEdit:9970572] Orlic-Milacic, Marija, 2025-10-30 [InstanceEdit:9970651] Orlic-Milacic, Marija, 2025-10-31 [InstanceEdit:9970852] Orlic-Milacic, Marija, 2025-11-03 [InstanceEdit:9971059] Orlic-Milacic, Marija, 2025-11-04 [InstanceEdit:9971426] Orlic-Milacic, Marija, 2025-11-06 [InstanceEdit:9971473] Orlic-Milacic, Marija, 2025-11-06 [InstanceEdit:9971582] Orlic-Milacic, Marija, 2025-11-07 [InstanceEdit:9971721] Orlic-Milacic, Marija, 2025-11-10
name	Recruitment of other CPA components to pre-mRNA-bound CPA core
negativePrecedingEvent	[NegativePrecedingEvent:9971460] Futile Cycle: CPA complex components dissociate from polyadenylated pre-mRNA (distal 3'UTR PAS) [NegativePrecedingEvent:9971459] Futile Cycle: CPA complex components dissociate from polyadenylated pre-mRNA (intronic PAS) [NegativePrecedingEvent:9971464] Futile Cycle: CPA complex components dissociate from polyadenylated pre-mRNA (proximal 3'UTR PAS)
output	[Complex:9970178] CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9970141] Core CPA complex binds capped pre-mRNA [Homo sapiens] [BlackBoxEvent:9770129] Formation of the Spliceosomal A complex [Homo sapiens] [Reaction:9770123] Formation of the core cleavage and polyadenylation complex [Homo sapiens] [Reaction:9770564] Formation of the CF II complex [Homo sapiens]
releaseDate	2025-12-08
reviewed	[InstanceEdit:9971220] Ahluwalia, Rhea, 2025-11-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9970186] R-HSA-9970179.1
structureModified	[InstanceEdit:9970251] Orlic-Milacic, Marija, 2025-10-29
summation	[Summation:9970213] Components of the cleavage and polyadenylation (CPA) comp...
(hasEvent)	[Pathway:9770562] mRNA Polyadenylation [Homo sapiens]
(precedingEvent)	[Reaction:9970190] PP1 dephosphorylates RNA Pol II [Homo sapiens]
(replacementInstances)	[_Deleted:9971718] Deletion of instance: 72231
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No pathways have been reviewed or authored by Recruitment of other CPA components to pre-mRNA-bound CPA core (9970179)