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Details on Person SRC-phosphorylated RAC1,(CDC42) GEFs activate RAC1,(CDC42)

Class:Id	BlackBoxEvent:9970163
_displayName	SRC-phosphorylated RAC1,(CDC42) GEFs activate RAC1,(CDC42)
_doRelease	TRUE
_timestamp	2026-03-09 13:26:36
authored	[InstanceEdit:9958936] Orlic-Milacic, Marija, 2025-06-25
catalystActivity	[CatalystActivity:9970165] guanyl-nucleotide exchange factor activity of SRC-phosphorylated RAC1/CDC42 GEFs [cytosol]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9970161] Orlic-Milacic, Marija, 2025-10-28
edited	[InstanceEdit:9984139] Orlic-Milacic, Marija, 2026-03-03
input	[CandidateSet:9959442] RAC1:GDP,(CDC42:GDP) [plasma membrane] [Homo sapiens] [SimpleEntity:29438] GTP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9644203] Phosphorylation and activation of the Rac1 and Cdc42 GEF Asef in A431 cells stimulated by EGF [LiteratureReference:5218543] VEGF-induced Rac1 activation in endothelial cells is regulated by the guanine nucleotide exchange factor Vav2 [LiteratureReference:9968182] Autocrine VEGF and IL-8 Promote Migration via Src/Vav2/Rac1/PAK1 Signaling in Human Umbilical Vein Endothelial Cells [LiteratureReference:9968517] The involvement of the tyrosine kinase c-Src in the regulation of reactive oxygen species generation mediated by NADPH oxidase-1 [LiteratureReference:9968535] Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII-driven glioblastoma tumorigenesis
modified	[InstanceEdit:9975426] Orlic-Milacic, Marija, 2025-12-01 [InstanceEdit:9984518] Orlic-Milacic, Marija, 2026-03-09
name	SRC-phosphorylated RAC1,(CDC42) GEFs activate RAC1,(CDC42)
output	[CandidateSet:9959034] RAC1:GTP,(CDC42:GTP) [plasma membrane] [Homo sapiens] [SimpleEntity:29420] GDP [cytosol]
precedingEvent	[BlackBoxEvent:9958892] SRC promotes RAC1 and CDC42 activation by phosphorylating RAC1 and CDC42 GEFs [Homo sapiens]
releaseDate	2026-03-25
reviewed	[InstanceEdit:9975417] Raptis, Leda, 2025-11-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9970166] R-HSA-9970163.1
summation	[Summation:9970164] SRC-phosphorylated RAC1/CDC42 guanine nucleotide exchange...
(hasEvent)	[Pathway:9958810] SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST) [Homo sapiens]
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No pathways have been reviewed or authored by SRC-phosphorylated RAC1,(CDC42) GEFs activate RAC1,(CDC42) (9970163)