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Details on Person Core CPA complex binds capped pre-mRNA

Class:Id	Reaction:9970141
_displayName	Core CPA complex binds capped pre-mRNA
_doRelease	TRUE
_timestamp	2025-11-07 16:29:46
authored	[InstanceEdit:9770563] Ahluwalia, Rhea, 2025-10-01
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9970142] Orlic-Milacic, Marija, 2025-10-28
edited	[InstanceEdit:9971425] Orlic-Milacic, Marija, 2025-11-06
input	[Complex:9970121] Core CPA complex [nucleoplasm] [Homo sapiens] [Complex:9770140] Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9971552] May, Bruce, 2025-11-07
isChimeric	FALSE
literatureReference	[LiteratureReference:9970146] 3' end formation of pre-mRNA and phosphorylation of Ser2 on the RNA polymerase II CTD are reciprocally coupled in human cells [LiteratureReference:9969086] Crystal structure of a human cleavage factor CFI(m)25/CFI(m)68/RNA complex provides an insight into poly(A) site recognition and RNA looping [LiteratureReference:9970153] CPSF30 and Wdr33 directly bind to AAUAAA in mammalian mRNA 3' processing [LiteratureReference:9969152] Molecular basis for the recognition of the human AAUAAA polyadenylation signal [LiteratureReference:9969180] Structural insights into the assembly and polyA signal recognition mechanism of the human CPSF complex [LiteratureReference:9969181] Biophysical characterizations of the recognition of the AAUAAA polyadenylation signal [LiteratureReference:8938788] Reconstitution of CPSF active in polyadenylation: recognition of the polyadenylation signal by WDR33 [LiteratureReference:9970114] The 64-kilodalton subunit of the CstF polyadenylation factor binds to pre-mRNAs downstream of the cleavage site and influences cleavage site location [LiteratureReference:9970112] Human CSTF2 RNA Recognition Motif Domain Binds to a U-Rich RNA Sequence through a Multistep Binding Process [LiteratureReference:9970092] The structural basis of CstF-77 modulation of cleavage and polyadenylation through stimulation of CstF-64 activity [LiteratureReference:9970105] Reconstitution of the CstF complex unveils a regulatory role for CstF-50 in recognition of 3'-end processing signals [LiteratureReference:8938804] Complex protein interactions within the human polyadenylation machinery identify a novel component [LiteratureReference:8938785] Overlapping and distinct functions of CstF64 and CstF64τ in mammalian mRNA 3' processing [LiteratureReference:9970456] Suboptimal RNA-RNA interaction limits U1 snRNP inhibition of canonical mRNA 3' processing [LiteratureReference:9971357] Mechanism of poly(A) signal transduction to RNA polymerase II in vitro
modified	[InstanceEdit:9970150] Orlic-Milacic, Marija, 2025-10-28 [InstanceEdit:9970155] Orlic-Milacic, Marija, 2025-10-28 [InstanceEdit:9970156] Orlic-Milacic, Marija, 2025-10-28 [InstanceEdit:9970172] Orlic-Milacic, Marija, 2025-10-28 [InstanceEdit:9970437] Orlic-Milacic, Marija, 2025-10-30 [InstanceEdit:9970459] Orlic-Milacic, Marija, 2025-10-30 [InstanceEdit:9970651] Orlic-Milacic, Marija, 2025-10-31 [InstanceEdit:9971059] Orlic-Milacic, Marija, 2025-11-04 [InstanceEdit:9971358] Orlic-Milacic, Marija, 2025-11-05 [InstanceEdit:9971426] Orlic-Milacic, Marija, 2025-11-06 [InstanceEdit:9971582] Orlic-Milacic, Marija, 2025-11-07
name	Core CPA complex binds capped pre-mRNA
output	[Complex:9970140] Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9770129] Formation of the Spliceosomal A complex [Homo sapiens] [BlackBoxEvent:9770119] Formation of the Spliceosomal E complex [Homo sapiens] [Reaction:9770123] Formation of the core cleavage and polyadenylation complex [Homo sapiens] [Reaction:9770557] Formation of the CF I complex [Homo sapiens] [Reaction:9770560] Formation of the CPSF complex [Homo sapiens] [Reaction:9770559] Formation of the CSTF complex [Homo sapiens]
releaseDate	2025-12-08
reviewed	[InstanceEdit:9971220] Ahluwalia, Rhea, 2025-11-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9970143] R-HSA-9970141.1
summation	[Summation:9970148] RNA polymerase II (RNA Pol II) slows around the polyA sig...
(hasEvent)	[Pathway:9770562] mRNA Polyadenylation [Homo sapiens]
(precedingEvent)	[Reaction:9970179] Recruitment of other CPA components to pre-mRNA-bound CPA core [Homo sapiens]
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No pathways have been reviewed or authored by Core CPA complex binds capped pre-mRNA (9970141)