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Details on Person RUVBL1:RUVBL2 hydrolyze ATP

Class:Id	Reaction:9969875
_displayName	RUVBL1:RUVBL2 hydrolyze ATP
_timestamp	2026-02-06 20:29:48
catalystActivity	[CatalystActivity:9969874] ATP hydrolysis activity of HSP90:R2TP:DNAAF co-chaperone complex [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9969876] Rothfels, Karen, 2025-10-23
input	[SimpleEntity:29356] H2O [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[Book:9969494] Desai, PB Cytoplasmic preassembly and trafficking of axonemal dyneins Dyneins Structure Biology and Disease in "Dyneins Structure Biology and Disease" [LiteratureReference:9968932] Role of the Novel Hsp90 Co-Chaperones in Dynein Arms' Preassembly [LiteratureReference:9981029] RUVBL1-RUVBL2 AAA-ATPase: a versatile scaffold for multiple complexes and functions [LiteratureReference:9968975] The Role of Hsp90-R2TP in Macromolecular Complex Assembly and Stabilization [LiteratureReference:9981043] Targeted deletion of the AAA-ATPase Ruvbl1 in mice disrupts ciliary integrity and causes renal disease and hydrocephalus [LiteratureReference:9968785] Axonemal dynein assembly requires the R2TP complex component Pontin [LiteratureReference:9970758] DNAAF1 links heart laterality with the AAA+ ATPase RUVBL1 and ciliary intraflagellar transport [LiteratureReference:9968966] The RPAP3-Cterminal domain identifies R2TP-like quaternary chaperones [LiteratureReference:9969655] Assembly principles of the human R2TP chaperone complex reveal the presence of R2T and R2P complexes
modified	[InstanceEdit:9981060] Rothfels, Karen, 2026-02-04 [InstanceEdit:9981294] Rothfels, Karen, 2026-02-06
name	RUVBL1:RUVBL2 hydrolyze ATP
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:9969871] R2TP- and HSP90-chaperone complexes associate [Homo sapiens] [Reaction:9969868] DNAAF10 binds the R2TP-like complex [Homo sapiens] [Reaction:9969529] HSP90 hydrolyzes ATP [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9969877] R-HSA-9969875.1
summation	[Summation:9981057] Assembly of the inner and outer dynein arms (IDA and ODA, re...
(hasEvent)	[Pathway:9969543] Assembly of the epithelial motile axoneme [Homo sapiens]
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No pathways have been reviewed or authored by RUVBL1:RUVBL2 hydrolyze ATP (9969875)