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Details on Person R2TP- and HSP90-chaperone complexes associate

Class:Id	Reaction:9969871
_displayName	R2TP- and HSP90-chaperone complexes associate
_timestamp	2025-12-12 20:37:25
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9969872] Rothfels, Karen, 2025-10-23
input	[Complex:9969828] RUVBL1:RUVBL2 dodecamer:RPAP3-like:PIH1D-like:DNAAF10 [cytosol] [Homo sapiens] [Complex:9969530] HSP90 dimer:FKBP8:ZMYND10:DNAAF11 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9968932] Role of the Novel Hsp90 Co-Chaperones in Dynein Arms' Preassembly [LiteratureReference:9968975] The Role of Hsp90-R2TP in Macromolecular Complex Assembly and Stabilization [Book:9969494] Desai, PB Cytoplasmic preassembly and trafficking of axonemal dyneins Dyneins Structure Biology and Disease in "Dyneins Structure Biology and Disease" [LiteratureReference:9969673] RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex [LiteratureReference:9976684] The role of SPAG1 in the assembly of axonemal dyneins in human airway epithelia [LiteratureReference:9969032] ZMYND10 stabilizes intermediate chain proteins in the cytoplasmic pre-assembly of dynein arms [LiteratureReference:9968807] Cytoplasmic factories for axonemal dynein assembly [LiteratureReference:9969764] X-linked primary ciliary dyskinesia due to mutations in the cytoplasmic axonemal dynein assembly factor PIH1D3
modified	[InstanceEdit:9975967] Rothfels, Karen, 2025-12-04 [InstanceEdit:9976691] Rothfels, Karen, 2025-12-12
name	R2TP- and HSP90-chaperone complexes associate
output	[Complex:9969834] HSP90:R2TP:DNAAF co-chaperone complex [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9969868] DNAAF10 binds the R2TP-like complex [Homo sapiens] [Reaction:9969856] RPAP3:PIH1-like dimers bind RUVBL1:RUVBL2 [Homo sapiens] [Reaction:9969529] HSP90 hydrolyzes ATP [Homo sapiens] [Reaction:9969495] DNAAF11:ZMYND10 bind HSP90 dimer:FKBP8 [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9969873] R-HSA-9969871.1
summation	[Summation:9975969] The molecular chaperone HSP90 and the multisubunit R2TP comp...
(hasEvent)	[Pathway:9969543] Assembly of the epithelial motile axoneme [Homo sapiens]
(precedingEvent)	[Reaction:9969875] RUVBL1:RUVBL2 hydrolyze ATP [Homo sapiens]
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No pathways have been reviewed or authored by R2TP- and HSP90-chaperone complexes associate (9969871)