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Details on Person DNAAF10 binds the R2TP-like complex

Class:Id	Reaction:9969868
_displayName	DNAAF10 binds the R2TP-like complex
_timestamp	2025-10-23 20:23:46
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9969869] Rothfels, Karen, 2025-10-23
input	[EntityWithAccessionedSequence:9969829] DNAAF10 [cytosol] [Homo sapiens] [Complex:9969824] RUVBL1:RUVBL2 dodecamer:RPAP3-like:PIH1D-like [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9969685] Molecular cloning of novel Monad binding protein containing tetratricopeptide repeat domains [LiteratureReference:9969656] Discrete PIH proteins function in the cytoplasmic preassembly of different subsets of axonemal dyneins [LiteratureReference:9969677] Deep Structural Analysis of RPAP3 and PIH1D1, Two Components of the HSP90 Co-chaperone R2TP Complex [LiteratureReference:9969673] RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex [LiteratureReference:9968966] The RPAP3-Cterminal domain identifies R2TP-like quaternary chaperones [LiteratureReference:9968807] Cytoplasmic factories for axonemal dynein assembly [LiteratureReference:9968975] The Role of Hsp90-R2TP in Macromolecular Complex Assembly and Stabilization [LiteratureReference:9969737] Chlamydomonas WDR92 in association with R2TP-like complex and multiple DNAAFs to regulate ciliary dynein preassembly [LiteratureReference:9969771] Ciliary dynein motor preassembly is regulated by Wdr92 in association with HSP90 co-chaperone, R2TP [LiteratureReference:9969697] A prefoldin-associated WD-repeat protein (WDR92) is required for the correct architectural assembly of motile cilia [LiteratureReference:9969705] WDR92 is required for axonemal dynein heavy chain stability in cytoplasm [LiteratureReference:9969740] Mutations in SPAG1 cause primary ciliary dyskinesia associated with defective outer and inner dynein arms [LiteratureReference:9969733] R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein [LiteratureReference:9969672] Probabilistic assembly of human protein interaction networks from label-free quantitative proteomics [LiteratureReference:9969706] HSP90 and its R2TP/Prefoldin-like cochaperone are involved in the cytoplasmic assembly of RNA polymerase II [LiteratureReference:9969642] HSP90 and the R2TP co-chaperone complex: building multi-protein machineries essential for cell growth and gene expression
name	DNAAF10 binds the R2TP-like complex
output	[Complex:9969828] RUVBL1:RUVBL2 dodecamer:RPAP3-like:PIH1D-like:DNAAF10 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9969856] RPAP3:PIH1-like dimers bind RUVBL1:RUVBL2 [Homo sapiens] [Reaction:9969859] RPAP3-like proteins bind PIH1D-like proteins [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9969870] R-HSA-9969868.1
summation	[Summation:9969867] RPAP3 recruits DNAAF10 (also known as WDR92) to the R2TP-lik...
(hasEvent)	[Pathway:9969543] Assembly of the epithelial motile axoneme [Homo sapiens]
(precedingEvent)	[Reaction:9969871] R2TP- and HSP90-chaperone complexes associate [Homo sapiens]
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