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Details on Person ODA heavy and intermediate chains recruit light chains

Class:Id	Reaction:9969540
_displayName	ODA heavy and intermediate chains recruit light chains
_timestamp	2026-02-06 20:29:38
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9969539] Rothfels, Karen, 2025-10-22
input	[Complex:9969282] DNAI1:DNAI2:DNAI5:(DNAI9,DNAI11) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9969291] DNAL1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9969293] DYNLT2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9969284] NME8 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:6801602] DYNLT1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:6801602] DYNLT1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:387105] DYNLL1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:387105] DYNLL1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9969264] DYNLRB1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9969250] DYNLRB2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9969280] DNAL4 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9969280] DNAL4 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[Book:9969852] King, Stephen M Composition and assembly of axonemal dyneins "Composition and assembly of axonemal dyneins" in Dyneins Structure Biology and Disease [LiteratureReference:9981263] Potential role for phosphorylation in differential regulation of the assembly of dynein light chains [LiteratureReference:9981248] Differential light chain assembly influences outer arm dynein motor function [LiteratureReference:9981269] Solution structure of isoform 1 of Roadblock/LC7, a light chain in the dynein complex [LiteratureReference:9966975] Consensus nomenclature for dyneins and associated assembly factors [LiteratureReference:5626120] A dynein light chain is essential for the retrograde particle movement of intraflagellar transport (IFT) [LiteratureReference:9981244] Cytoplasmic dynein (ddlc1) mutations cause morphogenetic defects and apoptotic cell death in Drosophila melanogaster [LiteratureReference:9981255] Identification and analysis of axonemal dynein light chain 1 in primary ciliary dyskinesia patients [LiteratureReference:9981265] Primary ciliary dyskinesia caused by homozygous mutation in DNAL1, encoding dynein light chain 1 [LiteratureReference:9981233] Axonemal dynein light chain-1 locates at the microtubule-binding domain of the γ heavy chain [LiteratureReference:9969740] Mutations in SPAG1 cause primary ciliary dyskinesia associated with defective outer and inner dynein arms [LiteratureReference:9980602] Motile cilia and airway disease [LiteratureReference:9968926] Primary Ciliary Dyskinesia: A Clinical Review [LiteratureReference:9981226] A common variant in combination with a nonsense mutation in a member of the thioredoxin family causes primary ciliary dyskinesia [LiteratureReference:9981276] The mammalian Nm23/NDPK family: from metastasis control to cilia movement
modified	[InstanceEdit:9981293] Rothfels, Karen, 2026-02-06
name	ODA heavy and intermediate chains recruit light chains
output	[Complex:9969292] outer dynein arm [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9969519] DNAI1:DNAI2 bind DNAI5 and DNAI9,DNAI11 [Homo sapiens] [Reaction:9969515] DNAI1 binds DNAI2 [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9969541] R-HSA-9969540.1
summation	[Summation:9981284] Dynein light chains belong to one of three families, the DYN...
(hasEvent)	[Pathway:9969543] Assembly of the epithelial motile axoneme [Homo sapiens]
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No pathways have been reviewed or authored by ODA heavy and intermediate chains recruit light chains (9969540)