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Details on Person DNAI1 binds DNAI2

Class:Id	Reaction:9969515
_displayName	DNAI1 binds DNAI2
_timestamp	2026-02-06 20:31:43
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9969514] Rothfels, Karen, 2025-10-22
inferredFrom	[Reaction:9969448] ODA6 binds ODA9 [Chlamydomonas reinhardtii]
input	[EntityWithAccessionedSequence:9969294] DNAI1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9969289] DNAI2 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9968929] Protein-protein interactions in the 18S ATPase of Chlamydomonas outer dynein arms [LiteratureReference:9968986] The role of preassembled cytoplasmic complexes in assembly of flagellar dynein subunits [LiteratureReference:9968914] Mutations in axonemal dynein assembly factor DNAAF3 cause primary ciliary dyskinesia [LiteratureReference:9968785] Axonemal dynein assembly requires the R2TP complex component Pontin [LiteratureReference:9969032] ZMYND10 stabilizes intermediate chain proteins in the cytoplasmic pre-assembly of dynein arms [LiteratureReference:9968807] Cytoplasmic factories for axonemal dynein assembly [LiteratureReference:9969682] Whole-exome capture and sequencing identifies HEATR2 mutation as a cause of primary ciliary dyskinesia [LiteratureReference:9969653] Establishment of the early cilia preassembly protein complex during motile ciliogenesis [LiteratureReference:9968871] LRRC6 mutation causes primary ciliary dyskinesia with dynein arm defects [LiteratureReference:9968835] HEATR2 plays a conserved role in assembly of the ciliary motile apparatus [LiteratureReference:9968975] The Role of Hsp90-R2TP in Macromolecular Complex Assembly and Stabilization
modified	[InstanceEdit:9969878] Rothfels, Karen, 2025-10-23 [InstanceEdit:9981297] Rothfels, Karen, 2026-02-06
name	DNAI1 binds DNAI2
output	[Complex:9969287] DNAI1:DNAI2 [cytosol] [Homo sapiens]
regulatedBy	[PositiveRegulation:9969853] Positive regulation by 'DNAAF5:SPAG1:DNAAF2 [cytosol]' [PositiveRegulation:9981291] Positive regulation by 'HSP90:R2TP:DNAAF co-chaperone complex [cytosol]'
regulationReference	[RegulationReference:9969879] Positive regulation by 'DNAAF5:SPAG1:DNAAF2 [cytosol]' Establishment of the early cilia preassembly protein complex during motile ciliogenesis [RegulationReference:9981298] Positive regulation by 'HSP90:R2TP:DNAAF co-chaperone complex [cytosol]' Axonemal dynein assembly requires the R2TP complex component Pontin
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9969516] R-HSA-9969515.1
structureModified	[InstanceEdit:9969878] Rothfels, Karen, 2025-10-23 [InstanceEdit:9981297] Rothfels, Karen, 2026-02-06
summation	[Summation:9969052] Heterodimerization of the outer dynein arm (ODA) intermediat...
(hasEvent)	[Pathway:9969543] Assembly of the epithelial motile axoneme [Homo sapiens]
(precedingEvent)	[Reaction:9969519] DNAI1:DNAI2 bind DNAI5 and DNAI9,DNAI11 [Homo sapiens]
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No pathways have been reviewed or authored by DNAI1 binds DNAI2 (9969515)