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Details on Person DNAI3 (also known as WDR63), DNAI4 (WDR78) and DNAI7 (CFAP94...

Class:IdSummation:9969054
_displayNameDNAI3 (also known as WDR63), DNAI4 (WDR78) and DNAI7 (CFAP94...
_timestamp2026-02-18 21:19:13
created[InstanceEdit:9969048] Rothfels, Karen, 2025-10-20
modified[InstanceEdit:9976669] Rothfels, Karen, 2025-12-12
[InstanceEdit:9982741] Rothfels, Karen, 2026-02-18
textDNAI3 (also known as WDR63), DNAI4 (WDR78) and DNAI7 (CFAP94) are intermediate chain components of the two-headed inner dynein arm (IDA) I1/f. Intermediate chain proteins are critical initiators of dynein arm assembly, making contact with each other as well as other IDA components (Hendrickson et al, 2004; Hendrickson et al, 2013; Kamiya et al, 2014; Zhang et al, 2019; reviewed in Fabczak and Osinka, 2019; Braschi et al, 2022; King, 2021). In mouse, Dnai3/Wdr63 co-immunoprecipitates with Dnai4/Wdr138 and with the IDA I1/f heavy chains Dnah2 and Dnah10 and the light chain Dynlt1/Tctex1 (Zhang et al, 2018). In Chlamydomonas, IDA I1/f does not assemble in the absence of IC140 (DNAI3) (Perrone et al, 1998; Yang et al, 1998), and IC138 (DNAI4) is the site of assembly of a regulatory complex that additionally includes IC97 (DNAI7), FAP120 (no identified human homologue ) and light chain LC7b (DYNLRB1 or DYNLRB2) (VanderWaal et al, 2011; Wirschell et al, 2009; Bower et al, 2009; Ikeda et al, 2009; Hendrickson et al, 2004; Hendrickson 2014). In mouse, Dnai3/Wdr62 and Dnai4/Wdr78 have been shown to bind to tubulin, anchoring the IDA I1/f complex to the microtubules of the axoneme (Hendrickson et al, 2013). I1/f is located near the proximal end of the 96 nm repeat in the vicinity of radial spoke 1 (Mizuno et al, 2012; reviewed in Wirschell et al, 2007; King 2016; Viswanadha et al, 2017).
(summation)[Reaction:9969523] DNAI3 binds DNAI4 and DNAI7 [Homo sapiens]
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No pathways have been reviewed or authored by DNAI3 (also known as WDR63), DNAI4 (WDR78) and DNAI7 (CFAP94... (9969054)
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