Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Il6st protein stabilization by Cdh1,Cdh11

Class:IdBlackBoxEvent:9968619
_displayNameIl6st protein stabilization by Cdh1,Cdh11
_doReleaseTRUE
_timestamp2026-03-09 13:26:03
authored[InstanceEdit:9968599] Orlic-Milacic, Marija, 2025-10-17
compartment[Compartment:876] plasma membrane
created[InstanceEdit:9968621] Orlic-Milacic, Marija, 2025-10-17
edited[InstanceEdit:9984139] Orlic-Milacic, Marija, 2026-03-03
input[EntityWithAccessionedSequence:9968620] Il6st [plasma membrane] [Mus musculus]
isChimericFALSE
literatureReference[LiteratureReference:9958852] Activated Src requires Cadherin-11, Rac, and gp130 for Stat3 activation and survival of mouse Balb/c3T3 fibroblasts
[LiteratureReference:9968611] Extraneous E-Cadherin Engages the Deterministic Process of Somatic Reprogramming through Modulating STAT3 and Erk1/2 Activity
[LiteratureReference:9968616] E-cadherin is required for the proper activation of the Lifr/Gp130 signaling pathway in mouse embryonic stem cells
modified[InstanceEdit:9975420] Orlic-Milacic, Marija, 2025-12-01
[InstanceEdit:9984518] Orlic-Milacic, Marija, 2026-03-09
nameIl6st protein stabilization by Cdh1,Cdh11
regulatedBy[NegativeRegulation:9968623] Negative regulation by 'Engaged Cdh1,(Cdh11) [plasma membrane]'
releaseDate2026-03-25
reviewed[InstanceEdit:9975417] Raptis, Leda, 2025-11-21
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48892] Mus musculus
stableIdentifier[StableIdentifier:9968628] R-MMU-9968619.1
summation[Summation:9968622] Cdh1 (del Valle et al. 2013: recombinant CDH1 of unspecified...
(inferredFrom)[BlackBoxEvent:9968598] CDH1,CDH11 promote stabilization of IL6ST protein [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by Il6st protein stabilization by Cdh1,Cdh11 (9968619)