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Details on Person Guanylate-binding protein 1 (GBP1) activity is tightly regul...
| Class:Id | Summation:9968555 |
|---|---|
| _displayName | Guanylate-binding protein 1 (GBP1) activity is tightly regul... |
| _timestamp | 2025-10-16 05:26:20 |
| created | [InstanceEdit:9968554] Shamovsky, Veronica, 2025-10-16 |
| literatureReference | [LiteratureReference:9956737] Human GBP1 Differentially Targets Salmonella and Toxoplasma to License Recognition of Microbial Ligands and Caspase-Mediated Death [LiteratureReference:9954264] PIM1 controls GBP1 activity to limit self-damage and to guard against pathogen infection [LiteratureReference:9954254] GTP is an allosteric modulator of the interaction between the guanylate-binding protein 1 and the prosurvival kinase PIM1 [LiteratureReference:9954245] Identification of the first inhibitor of the GBP1:PIM1 interaction. Implications for the development of a new class of anticancer agents against paclitaxel resistant cancer cells [LiteratureReference:9954189] Class III β-tubulin and the cytoskeletal gateway for drug resistance in ovarian cancer |
| text | Guanylate-binding protein 1 (GBP1) activity is tightly regulated to balance antimicrobial defense and prevent excessive inflammation. Caspase-1 (CASP1) cleaves GBP1 at aspartate 192 (D192), producing inactive fragments that lose the ability to target intracellular Salmonella Typhimurium, recruit caspase-4 (CASP4), or induce pyroptosis. This cleavage acts as a feedback mechanism to limit pyroptotic cell death during bacterial infection but does not occur during Toxoplasma gondii infection, indicating pathogen-specific regulation (Naschberger E et al., 2017; Fisch D et al., 2020). The kinase PIM1 phosphorylates GBP1 at Ser156 and Thr590, with Ser156 phosphorylation promoting binding to 14-3-3σ (SFN), which sequesters GBP1 in the cytosol and suppresses its membrane-associated antimicrobial activity (Fisch D et al., 2023). GTP binding disrupts the PIM1:GBP1 complex through an allosteric mechanism, highlighting how GBP1 integrates nucleotide- and phosphorylation-dependent control to fine-tune host defense (Persico M et al., 2015; De Donato M et al., 2012; Andreoli M et al., 2014). |
| (summation) | [Pathway:9968551] Regulation of GBP-mediated host defense [Homo sapiens] |
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No pathways have been reviewed or authored by Guanylate-binding protein 1 (GBP1) activity is tightly regul... (9968555)
