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Details on Person Aicda at immunoglobulin variable region deaminates deoxycytidine yielding deoxyuridine

Class:Id	Reaction:9967595
_displayName	Aicda at immunoglobulin variable region deaminates deoxycytidine yielding deoxyuridine
_doRelease	TRUE
_timestamp	2026-04-27 18:34:21
authored	[InstanceEdit:9967588] May, Bruce, 2025-10-04
catalystActivity	[CatalystActivity:9967596] cytidine deaminase activity of Aicda:Ig gene:Arrested RNA polymerase II complex:RNA:RNA exosome [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9967597] May, Bruce, 2025-10-04
edited	[InstanceEdit:9967588] May, Bruce, 2025-10-04
input	[GenomeEncodedEntity:9967598] 2'-deoxycytidine in single-stranded DNA [nucleoplasm] [Mus musculus] [SimpleEntity:9668967] H+ [nucleoplasm] [SimpleEntity:113518] H2O [nucleoplasm]
internalReviewed	[InstanceEdit:9980588] Matthews, Lisa, 2026-01-30
isChimeric	FALSE
literatureReference	[LiteratureReference:9943137] AID function in somatic hypermutation and class switch recombination [LiteratureReference:9947038] Transcription-targeted DNA deamination by the AID antibody diversification enzyme [LiteratureReference:9947065] Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells [LiteratureReference:9938376] Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
modified	[InstanceEdit:9983648] May, Bruce, 2026-02-25 [InstanceEdit:9983927] May, Bruce, 2026-02-28 [InstanceEdit:9987736] May, Bruce, 2026-04-27
name	Aicda at immunoglobulin variable region deaminates deoxycytidine yielding deoxyuridine
output	[GenomeEncodedEntity:9967599] 2'-deoxyuridine in single-stranded DNA [nucleoplasm] [Mus musculus] [SimpleEntity:9822968] NH4+ [nucleoplasm]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2026-06-17
reviewed	[InstanceEdit:9987727] Yu, Chuanjiang, 2026-04-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:9967606] R-MMU-9967595.1
summation	[Summation:9967592] Aicda (Aid) deaminates cytidine residues (Muramatsu et al. 1...
(inferredFrom)	[Reaction:9943255] AICDA at immunoglobulin variable region deaminates deoxycytidine yielding deoxyuridine [Homo sapiens]
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No pathways have been reviewed or authored by Aicda at immunoglobulin variable region deaminates deoxycytidine yielding deoxyuridine (9967595)