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Details on Person The BHC (BRAF-HDAC) complex is involved in the repression of...
| Class:Id | Summation:996749 |
|---|---|
| _displayName | The BHC (BRAF-HDAC) complex is involved in the repression of... |
| _timestamp | 2010-11-10 17:58:44 |
| created | [InstanceEdit:996739] Jupe, S, 2010-11-08 |
| literatureReference | [LiteratureReference:996738] An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation [LiteratureReference:996750] The many faces of REST oversee epigenetic programming of neuronal genes |
| modified | [InstanceEdit:1008204] Jupe, S, 2010-11-10 |
| text | The BHC (BRAF-HDAC) complex is involved in the repression of neuronal-specific genes during development. It is recruited by RE1-silencing transcription factor (REST) to mediate the repression of REST-responsive genes. The BHC complex includes histone deacetylases (HDACs) 1 and 2, and the histone demethylase KDM1A (also knowns as BHC110, LSD1 or AOF2). KDM1A demethylates both Lys-4 (H3K4me) and Lys-9 (H3K9me) of histone H3, acting as a coactivator or a corepressor, depending on the context. Corepressor for element-1-silencing transcription factor (CoREST) is an essential component of the BHC complex, enhancing the association with nucleosomes (Lee et al. 2005). REST is a modular transcriptional regulator that recruits CoREST and other regulatory cofactors to activate or repress transcription through dynamic epigenetic mechanisms (Ballas & Mandel 2005). |
| (summation) | [Reaction:996727] REST recruits the BHC complex [Homo sapiens] |
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No pathways have been reviewed or authored by The BHC (BRAF-HDAC) complex is involved in the repression of... (996749)
