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Details on Person Stat3 and Fosb:Jund (AP-1) positively regulate expression of Bcl6

Class:Id	BlackBoxEvent:9967164
_displayName	Stat3 and Fosb:Jund (AP-1) positively regulate expression of Bcl6
_doRelease	TRUE
_timestamp	2026-04-27 18:38:07
authored	[InstanceEdit:9966585] May, Bruce, 2025-09-22
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9967173] May, Bruce, 2025-09-27
edited	[InstanceEdit:9966585] May, Bruce, 2025-09-22
input	[EntityWithAccessionedSequence:9967167] Bcl6 gene [nucleoplasm] [Mus musculus]
internalReviewed	[InstanceEdit:9980588] Matthews, Lisa, 2026-01-30
isChimeric	FALSE
literatureReference	[LiteratureReference:9942476] Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity [LiteratureReference:9942477] IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses [LiteratureReference:9942413] IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism [LiteratureReference:9942435] JunD/AP-1 and STAT3 are the major enhancer molecules for high Bcl6 expression in germinal center B cells [LiteratureReference:9942463] The molecular basis of IL-21-mediated proliferation
modified	[InstanceEdit:9983648] May, Bruce, 2026-02-25 [InstanceEdit:9983927] May, Bruce, 2026-02-28 [InstanceEdit:9987736] May, Bruce, 2026-04-27
name	Stat3 and Fosb:Jund (AP-1) positively regulate expression of Bcl6
output	[EntityWithAccessionedSequence:9967170] Bcl6 [nucleoplasm] [Mus musculus]
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[PositiveGeneExpressionRegulation:9967172] Positive gene expression regulation by 'Stat3:Fosb:Jund:Bcl6 gene [nucleoplasm]'
releaseDate	2026-06-17
reviewed	[InstanceEdit:9987727] Yu, Chuanjiang, 2026-04-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:9967178] R-MMU-9967164.1
summation	[Summation:9967166] Bcl6 is upregulated after antigen engagement of the B cell r...
(inferredFrom)	[BlackBoxEvent:9942461] STAT3 and FOSB:JUND (AP-1) positively regulate expression of BCL6 in germinal center B cells [Homo sapiens]
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No pathways have been reviewed or authored by Stat3 and Fosb:Jund (AP-1) positively regulate expression of Bcl6 (9967164)