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Details on Person In the thyroid follicle lumen, thyroglobulin (TG) undergoes ...
| Class:Id | Summation:9966618 |
|---|---|
| _displayName | In the thyroid follicle lumen, thyroglobulin (TG) undergoes ... |
| _timestamp | 2025-09-24 09:05:25 |
| created | [InstanceEdit:9966620] Stephan, Ralf, 2025-09-23 |
| modified | [InstanceEdit:9966645] Stephan, Ralf, 2025-09-24 |
| text | In the thyroid follicle lumen, thyroglobulin (TG) undergoes multimerization via intermolecular disulfide bonds to form insoluble colloid globules. Evidence suggests at least two mechanisms for this process. This reaction shows protein disulfide isomerase (PDI), which is found in human colloid globules (Berndorfer et al., 1996), catalyzing the process. In vitro, P4HB (PDI) has been shown to catalyze the oligomerization of unfolded bovine TG in a redox-dependent manner (Liu & Sok, 2002). |
| (summation) | [BlackBoxEvent:9967031] P4HB oligomerizes iodinated TG [Bos taurus] |
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No pathways have been reviewed or authored by In the thyroid follicle lumen, thyroglobulin (TG) undergoes ... (9966618)
