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Details on Person As germinal centers develop, Tfh cells progressively increas...
| Class:Id | Summation:9966566 |
|---|---|
| _displayName | As germinal centers develop, Tfh cells progressively increas... |
| _timestamp | 2026-04-26 21:29:02 |
| created | [InstanceEdit:9966568] May, Bruce, 2025-09-22 |
| modified | [InstanceEdit:9987698] May, Bruce, 2026-04-26 |
| text | As germinal centers develop, Tfh cells progressively increase Il-4 production while maintaining Il-21 production, which acts with Cd40l to promote differentiation of antibody secreting B cells (Weinstein et al. 2016). Tfh cells secrete almost all of the Il4 found in lymph nodes (Reinhardt et al. 2009, King and Mohrs 2009). Batf, Irf4, Stat3, and Stat6 bind the conserved non-coding sequence 2 (CNS2) of the Il4 gene and activate transcription (Sahoo et al. 2015). The receptor Slamf1 (CD150) is required for expression of Il4 in Tfh cells (Yusuf et al. 2010). |
| (summation) | [BlackBoxEvent:9966560] Expression of Il4 in T follicular help cells [Mus musculus] |
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No pathways have been reviewed or authored by As germinal centers develop, Tfh cells progressively increas... (9966566)
