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Details on Person Expression of Il4 in T follicular help cells

Class:Id	BlackBoxEvent:9966560
_displayName	Expression of Il4 in T follicular help cells
_doRelease	TRUE
_timestamp	2026-04-27 18:36:17
authored	[InstanceEdit:9966553] May, Bruce, 2025-09-22
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9966568] May, Bruce, 2025-09-22
edited	[InstanceEdit:9966553] May, Bruce, 2025-09-22
input	[EntityWithAccessionedSequence:9945873] Il4 gene [nucleoplasm] [Mus musculus]
internalReviewed	[InstanceEdit:9980588] Matthews, Lisa, 2026-01-30
isChimeric	FALSE
literatureReference	[LiteratureReference:9942248] Batf is important for IL-4 expression in T follicular helper cells [LiteratureReference:9942214] TFH cells progressively differentiate to regulate the germinal center response [LiteratureReference:9946562] Cytokine-secreting follicular T cells shape the antibody repertoire [LiteratureReference:9946619] IL-4-producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells [LiteratureReference:9981135] Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150)
modified	[InstanceEdit:9981143] May, Bruce, 2026-02-05 [InstanceEdit:9983648] May, Bruce, 2026-02-25 [InstanceEdit:9983927] May, Bruce, 2026-02-28 [InstanceEdit:9987736] May, Bruce, 2026-04-27
name	Expression of Il4 in T follicular help cells
output	[EntityWithAccessionedSequence:9966547] Il4 [extracellular region] [Mus musculus]
participantCellType	[PhysicalEntityCellType:9966557] Il4 gene [nucleoplasm] in T follicular helper cell (Tfh) (mouse)
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[PositiveGeneExpressionRegulation:9966551] Positive gene expression regulation by 'Batf:Irf4:Stat3:Stat6:Il4 gene [nucleoplasm]'
releaseDate	2026-06-17
requiredInputComponent	[EntityWithAccessionedSequence:9966543] Slamf1 [plasma membrane] [Mus musculus]
reviewed	[InstanceEdit:9987727] Yu, Chuanjiang, 2026-04-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:9966581] R-MMU-9966560.1
summation	[Summation:9966566] As germinal centers develop, Tfh cells progressively increas...
(inferredFrom)	[BlackBoxEvent:9942221] Expression of IL4 in T follicular help cells [Homo sapiens]
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