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NSP1 (also known as NS53) is the product of the rotavirus...
| Class:Id | Summation:9966159 |
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| _displayName | NSP1 (also known as NS53) is the product of the rotavirus... |
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| _timestamp | 2026-01-19 23:29:16 |
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| created | [InstanceEdit:9966160] Orlic-Milacic, Marija, 2025-09-11 |
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| literatureReference | [LiteratureReference:9966147] Efficient translation of rotavirus mRNA requires simultaneous interaction of NSP3 with the eukaryotic translation initiation factor eIF4G and the mRNA 3' end
[LiteratureReference:9966188] Rotavirus NSP3 Is a Translational Surrogate of the Poly(A) Binding Protein-Poly(A) Complex
[LiteratureReference:9974090] Structure and function of rotavirus NSP1
[LiteratureReference:9974087] Functional analysis of the heterologous NSP1 genes in the genetic background of simian rotavirus SA11
[LiteratureReference:9974177] Post-translational regulation of rotavirus protein NSP1 expression in mammalian cells
[LiteratureReference:9974178] Deletion mapping of the rotavirus metalloprotein NS53 (NSP1): the conserved cysteine-rich region is essential for virus-specific RNA binding
[LiteratureReference:9974196] Permissive replication of homologous murine rotavirus in the mouse intestine is primarily regulated by VP4 and NSP1
[LiteratureReference:9974201] Roles of VP4 and NSP1 in determining the distinctive replication capacities of simian rotavirus RRV and bovine rotavirus UK in the mouse biliary tract |
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| modified | [InstanceEdit:9966192] Orlic-Milacic, Marija, 2025-09-11
[InstanceEdit:9974092] Orlic-Milacic, Marija, 2025-11-19
[InstanceEdit:9974181] Orlic-Milacic, Marija, 2025-11-20
[InstanceEdit:9974199] Orlic-Milacic, Marija, 2025-11-20
[InstanceEdit:9974203] Orlic-Milacic, Marija, 2025-11-20
[InstanceEdit:9979464] Orlic-Milacic, Marija, 2026-01-19 |
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| text | NSP1 (also known as NS53) is the product of the rotavirus A (RV-A) gene 5 with a highly conserved cysteine-rich region that enables RNA binding (Hua et al. 1994: simian RV-A strain SA11 was used). NSP1 ranges in size from 486 to 495 amino acids, depending on the RV-A strain, and shows an overall high sequence diversity (Okada et al. 1999; reviewed in Taniguchi et al. 1996). NSP1 is susceptible to proteasome-mediated degradation, which is inhibited in the presence of viral mRNAs through an unknown mechanism (Piña-Vázquez et al. 2007). NSP1 is one of the RV-A factors that regulate permissiveness of viral replication in a host (Feng et al. 2011; Feng et al. 2013). The simultaneous interaction of NSP3 with RV-A mRNAs and the EIF4F complex is required for efficient mRNA translation (Vende et al. 2000, Gratia et al. 2015). |
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| (summation) | [BlackBoxEvent:9965297] Translation of RV-A NSP1 [Homo sapiens] |
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NSP1 (also known as NS53) is the product of the rotavirus... (9966159)
