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The VP3 gene of rotavirus A (RV-A) encodes the mRNA cappi...
| Class:Id | Summation:9966158 |
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| _displayName | The VP3 gene of rotavirus A (RV-A) encodes the mRNA cappi... |
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| _timestamp | 2026-01-20 02:31:04 |
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| created | [InstanceEdit:9966160] Orlic-Milacic, Marija, 2025-09-11 |
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| literatureReference | [LiteratureReference:9966147] Efficient translation of rotavirus mRNA requires simultaneous interaction of NSP3 with the eukaryotic translation initiation factor eIF4G and the mRNA 3' end
[LiteratureReference:9966188] Rotavirus NSP3 Is a Translational Surrogate of the Poly(A) Binding Protein-Poly(A) Complex
[LiteratureReference:9975983] Sequence analysis of the guanylyltransferase (VP3) of group A rotaviruses
[LiteratureReference:9821139] 2.7 Å cryo-EM structure of rotavirus core protein VP3, a unique capping machine with a helicase activity
[LiteratureReference:9973138] Characterization of rotavirus guanylyltransferase activity associated with polypeptide VP3
[LiteratureReference:9973103] Rotavirus VP3 expressed in insect cells possesses guanylyltransferase activity
[LiteratureReference:9973612] Rotavirus open cores catalyze 5'-capping and methylation of exogenous RNA: evidence that VP3 is a methyltransferase
[LiteratureReference:9975987] Distinguishing the genotype 1 genes and proteins of human Wa-like rotaviruses vs. porcine rotaviruses |
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| modified | [InstanceEdit:9966192] Orlic-Milacic, Marija, 2025-09-11
[InstanceEdit:9974985] Orlic-Milacic, Marija, 2025-11-27
[InstanceEdit:9975991] Orlic-Milacic, Marija, 2025-12-04
[InstanceEdit:9979469] Orlic-Milacic, Marija, 2026-01-20 |
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| text | The VP3 gene of rotavirus A (RV-A) encodes the mRNA capping enzyme (Kumar et al. 2020: rabbit RV-A strain 30-96 was used; Pizarro et al. 1991: simian RV-A strain SA11 and human RV-L , rotavirus L, were used; Liu et al. 1992: simian RV-A strain SA11 was used; Chen et al. 1999: simian RV-A strain SA11 was used) which forms a homotetramer (Kumar et al. 2020). VP3 protein of human RV-A Wa strain is 835 amino acids long, with highly conserved catalytic domains (Cook and McCrae 2004; Silva et al. 2016). The simultaneous interaction of NSP3 with RV-A mRNAs and the EIF4F complex is required for efficient mRNA translation (Vende et al. 2000, Gratia et al. 2015). |
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| (summation) | [BlackBoxEvent:9965295] Translation of RV-A VP3 [Homo sapiens] |
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The VP3 gene of rotavirus A (RV-A) encodes the mRNA cappi... (9966158)
