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Details on Person DIO3 dimer deiodinates T3 to T2

Class:IdReaction:9965908
_displayNameDIO3 dimer deiodinates T3 to T2
_timestamp2025-09-25 08:25:20
authored[InstanceEdit:9965901] Stephan, Ralf, 2025-09-07
catalystActivity[CatalystActivity:9965906] oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond of DIO3 dimer [plasma membrane]
compartment[Compartment:876] plasma membrane
created[InstanceEdit:9965910] Stephan, Ralf, 2025-09-07
crossReference[DatabaseIdentifier:9965904] RHEA:82573
input[SimpleEntity:9751056] GSH [extracellular region]
[SimpleEntity:9751056] GSH [extracellular region]
[SimpleEntity:352331] T3 [extracellular region]
internalReviewed[InstanceEdit:9967044] D'Eustachio, Peter, 2025-09-25
literatureReference[LiteratureReference:350871] Type 3 lodothyronine deiodinase: cloning, in vitro expression, and functional analysis of the placental selenoenzyme
[LiteratureReference:350850] Human type 3 iodothyronine selenodeiodinase is located in the plasma membrane and undergoes rapid internalization to endosomes
[LiteratureReference:9965639] Deiodinases and the Three Types of Thyroid Hormone Deiodination Reactions
[LiteratureReference:9965897] Substitution of cysteine for selenocysteine in the catalytic center of type III iodothyronine deiodinase reduces catalytic efficiency and alters substrate preference
modified[InstanceEdit:9966171] Stephan, Ralf, 2025-09-11
[InstanceEdit:9967043] Stephan, Ralf, 2025-09-25
nameDIO3 dimer deiodinates T3 to T2
output[SimpleEntity:3341331] GSSG [extracellular region]
[SimpleEntity:351626] H+ [extracellular region]
[SimpleEntity:209818] I- [extracellular region]
[SimpleEntity:9965909] T2 [extracellular region]
precedingEvent
reviewStatus[ReviewStatus:9821383] three stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9965911] R-HSA-9965908.1
summation[Summation:9965905] Type III iodothyronine deiodinase (DIO3) is an integral memb...
(hasEvent)[Pathway:9962042] NEW: Regulation of thyroid hormone activity [Homo sapiens]
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