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Details on Person EZHIP binds PRC2

Class:IdReaction:9965835
_displayNameEZHIP binds PRC2
_doReleaseFALSE
_timestamp2025-09-15 17:48:12
authored[InstanceEdit:9965840] Orlic-Milacic, Marija, 2025-09-05
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9965840] Orlic-Milacic, Marija, 2025-09-05
input[Complex:3211709] PRC2:Chromatin [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:9965839] EZHIP [nucleoplasm] [Homo sapiens]
internalReviewed[InstanceEdit:9966307] May, Bruce, 2025-09-11
isChimericFALSE
literatureReference[LiteratureReference:9965829] EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells
[LiteratureReference:9965936] PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism
[LiteratureReference:9965948] EZHIP/CXorf67 mimics K27M mutated oncohistones and functions as an intrinsic inhibitor of PRC2 function in aggressive posterior fossa ependymoma
[LiteratureReference:9965973] Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas
modified[InstanceEdit:9965946] Orlic-Milacic, Marija, 2025-09-08
[InstanceEdit:9965954] Orlic-Milacic, Marija, 2025-09-08
[InstanceEdit:9965976] Orlic-Milacic, Marija, 2025-09-08
[InstanceEdit:9966308] Orlic-Milacic, Marija, 2025-09-15
nameEZHIP binds PRC2
output[Complex:9965832] EZHIP:PRC2:Chromatin [nucleoplasm] [Homo sapiens]
reviewStatus[ReviewStatus:9821383] three stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9965843] R-HSA-9965835.1
summation[Summation:9965828] EZHIP (EZH1/2 Inhibitory Protein, also known as CXorf67), ex...
(hasEvent)[Pathway:212300] PRC2 methylates histones and DNA [Homo sapiens]
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