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Details on Person MLLT11 (AF1Q) forms a complex with TCF7

Class:IdReaction:9965427
_displayNameMLLT11 (AF1Q) forms a complex with TCF7
_doReleaseFALSE
_timestamp2025-09-03 14:10:56
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9965435] Orlic-Milacic, Marija, 2025-08-29
input[EntityWithAccessionedSequence:9965424] MLLT11 [nucleoplasm] [Homo sapiens]
[Complex:9965423] CTNNB1:TCF7 [nucleoplasm] [Homo sapiens]
internalReviewed[InstanceEdit:9965626] Rothfels, Karen, 2025-09-03
isChimericFALSE
literatureReference[LiteratureReference:9965438] AF1q is a novel TCF7 co-factor which activates CD44 and promotes breast cancer metastasis
[LiteratureReference:9965454] Recombinant expression and purification of AF1q and its interaction with T-cell Factor 7
modified[InstanceEdit:9965627] Orlic-Milacic, Marija, 2025-09-03
nameMLLT11 (AF1Q) forms a complex with TCF7
output[Complex:9965450] CTNNB1:TCF7:MLLT1 [nucleoplasm] [Homo sapiens]
precedingEvent
reviewStatus[ReviewStatus:9821383] three stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9965458] R-HSA-9965427.1
summation[Summation:9965431]

MLLT1 (also known as AF1Q or TCF7C), a small 9 kDa protei...

(hasEvent)[Pathway:201722] Formation of the beta-catenin:TCF transactivating complex [Homo sapiens]
(precedingEvent)[Reaction:9965437] The complex of MLLT11 and TCF7 binds CD44 gene promoter [Homo sapiens]
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