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Details on Person UniProt:P08556 Nras
| Class:Id | ReferenceGeneProduct:99645 |
|---|---|
| _chainChangeLog | chain:1-186 added on Fri February 6 2015;propeptide:187-189 added on Fri February 6 2015 |
| _displayName | UniProt:P08556 Nras |
| _timestamp | 2025-08-15 21:48:20 |
| chain | chain:1-186 propeptide:187-189 |
| checksum | 688D33F6814855B7 |
| comment | FUNCTION Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.CATALYTIC ACTIVITY GTP + H2O = GDP + phosphate + H(+)ACTIVITY REGULATION Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).SUBUNIT Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). Interacts (active GTP-bound form) with RASSF7 (By similarity). Interacts (active GTP-bound form) with both SHOC2 and PP1c (all isoforms) to form a tertiary complex; SHOC2 and PP1c preferably bind M-Ras/MRAS, but they also bind K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS (By similarity).SUBCELLULAR LOCATION Shuttles between the plasma membrane and the Golgi apparatus.PTM Palmitoylated by the ZDHHC9-GOLGA7 complex. Depalmitoylated by ABHD17A, ABHD17B and ABHD17C. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi.PTM Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs).PTM Ubiquitinated by the BCR(LZTR1) E3 ubiquitin ligase complex at Lys-170 in a non-degradative manner, leading to inhibit Ras signaling by decreasing Ras association with membranes.PTM Phosphorylation at Ser-89 enhances NRAS association with its downstream effectors.SIMILARITY Belongs to the small GTPase superfamily. Ras family. |
| description | recommendedName: GTPase NRas ecNumber evidence="4"3.6.5.2 alternativeName: Transforming protein N-Ras |
| geneName | Nras |
| identifier | P08556 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Cell membrane Golgi apparatus GTP-binding Hydrolase Isopeptide bond Lipoprotein Membrane Methylation Nucleotide-binding Palmitate Phosphoprotein Prenylation Proto-oncogene Reference proteome Ubl conjugation |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3132113] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5263031] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9698430] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | Nras |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | RASN_MOUSE |
| sequenceLength | 189 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:1250464] Nras [plasma membrane] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:P08556 Nras (99645)
