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Details on Person Interferon-induced protein with tetratricopeptide repeats 2 ...
| Class:Id | Summation:9962874 |
|---|---|
| _displayName | Interferon-induced protein with tetratricopeptide repeats 2 ... |
| _timestamp | 2025-08-11 13:35:48 |
| created | [InstanceEdit:9962894] Shamovsky, Veronica, 2025-08-11 |
| literatureReference | [LiteratureReference:9962861] Influenza virus repurposes the antiviral protein IFIT2 to promote translation of viral mRNAs [LiteratureReference:9962865] Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms |
| text | Interferon-induced protein with tetratricopeptide repeats 2 (IFIT2) binds to adenylate-uridylate (AU)-rich regions located in the 3′-UTRs of cellular mRNAs (Yang Z et al., 2012; Tran V et al., 2020), including numerous interferon-stimulated gene (ISG) products such as DDX58, STAT1, and members of the OAS and IFIT protein families (Tran V et al., 2020). This interaction is thought to enhance the translation of these AU-rich mRNAs by preventing ribosomal pausing (Tran V et al., 2020). |
| (summation) | [Reaction:9962876] IFIT2 binds AU-rich mRNA [Homo sapiens] |
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No pathways have been reviewed or authored by Interferon-induced protein with tetratricopeptide repeats 2 ... (9962874)
