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Details on Person Expression of PAX8 in the thyroid

Class:Id	BlackBoxEvent:9962478
_displayName	Expression of PAX8 in the thyroid
_doRelease	FALSE
_timestamp	2025-09-25 08:26:43
authored	[InstanceEdit:9962472] Stephan, Ralf, 2025-08-06
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9962477] Stephan, Ralf, 2025-08-07
goBiologicalProcess	[GO_BiologicalProcess:357904] positive regulation of transcription initiation by RNA polymerase II
input	[EntityWithAccessionedSequence:9761199] PAX8 gene [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9967044] D'Eustachio, Peter, 2025-09-25
isChimeric	FALSE
literatureReference	[LiteratureReference:9962468] Nevirapine Increases Sodium/Iodide Symporter-Mediated Radioiodide Uptake by Activation of TSHR/cAMP/CREB/PAX8 Signaling Pathway in Dedifferentiated Thyroid Cancer [LiteratureReference:9962466] SOX13 dependent PAX8 expression promotes the proliferation of gastric carcinoma cells [LiteratureReference:9659601] Crofelemer, a novel antisecretory agent approved for the treatment of HIV-associated diarrhea [LiteratureReference:9962839] Iodide Excess Inhibits Thyroid Hormone Synthesis Pathway Involving XBP1-Mediated Regulation
modified	[InstanceEdit:9962840] Stephan, Ralf, 2025-08-11 [InstanceEdit:9963918] Stephan, Ralf, 2025-08-18 [InstanceEdit:9964258] Stephan, Ralf, 2025-08-21 [InstanceEdit:9966179] Stephan, Ralf, 2025-09-11 [InstanceEdit:9966643] Stephan, Ralf, 2025-09-24 [InstanceEdit:9967043] Stephan, Ralf, 2025-09-25
name	Expression of PAX8 in the thyroid
output	[EntityWithAccessionedSequence:3968418] PAX8 [nucleoplasm] [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:9962470] Positive gene expression regulation by 'SOX13 [nucleoplasm]' [PositiveGeneExpressionRegulation:9624002] Positive gene expression regulation by 'p-S133-CREB1 homodimer [nucleoplasm]' [NegativeGeneExpressionRegulation:9962832] Negative gene expression regulation by 'XBP1 [nucleoplasm]'
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9962479] R-HSA-9962478.1
structureModified	[InstanceEdit:9962840] Stephan, Ralf, 2025-08-11
summation	[Summation:9962465] In human dedifferentiated thyroid cancer cells, PAX8 express...
(hasEvent)	[Pathway:9961434] Regulation of iodide transport [Homo sapiens]
(precedingEvent)	[Reaction:9962453] PAX8 binds PAX8 cofactors [Homo sapiens] [BlackBoxEvent:9963911] Expression of NKX2-1 [Homo sapiens] [BlackBoxEvent:9965224] Expression of HHEX in the thyroid [Homo sapiens] [BlackBoxEvent:9965323] Expression of TPO [Homo sapiens] [BlackBoxEvent:9965568] Expression of DUOX2 [Homo sapiens]
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No pathways have been reviewed or authored by Expression of PAX8 in the thyroid (9962478)