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Details on Person DEUP1 gene expression

Class:Id	BlackBoxEvent:9961986
_displayName	DEUP1 gene expression
_doRelease	TRUE
_timestamp	2026-05-08 19:12:52
authored	[InstanceEdit:9962119] Rothfels, Karen, 2025-07-31
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:9961985] Rothfels, Karen, 2025-07-29
edited	[InstanceEdit:9962258] Rothfels, Karen, 2025-07-31
input	[EntityWithAccessionedSequence:9961965] DEUP1 gene [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9962310] Orlic-Milacic, Marija, 2025-08-03
isChimeric	FALSE
literatureReference	[LiteratureReference:9961950] The Cep63 paralogue Deup1 enables massive de�novo centriole biogenesis for vertebrate multiciliogenesis [LiteratureReference:9961925] Deuterosome-mediated centriole biogenesis [LiteratureReference:9961910] Centriole biogenesis in multiciliated cells [LiteratureReference:9960682] Controlling centriole numbers: Geminin family members as master regulators of centriole amplification and multiciliogenesis [LiteratureReference:9961929] Emerging Picture of Deuterosome-Dependent Centriole Amplification in MCCs [LiteratureReference:9962088] Formation and function of multiciliated cells [LiteratureReference:9960341] Multicilin drives centriole biogenesis via E2f proteins [LiteratureReference:9961913] Conservation as well as divergence in Mcidas function underlies the differentiation of multiciliated cells in vertebrates [LiteratureReference:9960348] Cytoplasmic E2f4 forms organizing centres for initiation of centriole amplification during multiciliogenesis [LiteratureReference:9960338] Mcidas mutant mice reveal a two-step process for the specification and differentiation of multiciliated cells in mammals [LiteratureReference:9988631] Massive centriole production can occur in the absence of deuterosomes in multiciliated cells
modified	[InstanceEdit:9962107] Rothfels, Karen, 2025-07-31 [InstanceEdit:9962260] Rothfels, Karen, 2025-08-01 [InstanceEdit:9962312] Rothfels, Karen, 2025-08-03 [InstanceEdit:9988586] Rothfels, Karen, 2026-05-08 [InstanceEdit:9988640] Rothfels, Karen, 2026-05-08 [InstanceEdit:9988643] Rothfels, Karen, 2026-05-08
name	DEUP1 gene expression
output	[EntityWithAccessionedSequence:9961963] DEUP1 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9960756] MCIDAS dimer binds E2F4, E2F5 and TFDP1 [Homo sapiens] [BlackBoxEvent:9945716] GRHL2-dependent MCIDAS expression [Homo sapiens] [Reaction:9960746] MCIDAS dimerizes [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:9961978] Positive gene expression regulation by 'MCIDAS dimer:E2F4,E2F5:TFDP1 [nucleoplasm]'
regulationReference	[RegulationReference:9961987] Positive gene expression regulation by 'MCIDAS dimer:E2F4,E2F5:TFDP1 [nucleoplasm]' Multicilin drives centriole biogenesis via E2f proteins
releaseDate	2026-06-17
reviewed	[InstanceEdit:9988641] Dutcher, Susan K, 2026-05-08 [InstanceEdit:9988584] Rayamajhi, Dheeraj, 2026-05-08 [InstanceEdit:9988583] Roy, Sudipto, 2026-05-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9961988] R-HSA-9961986.1
summation	[Summation:9961975] DEUP1 (Deuterosome assembly protein 1) is a key component of...
(hasEvent)	[Pathway:9945556] Transcriptional regulation of multiciliogenesis [Homo sapiens]
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No pathways have been reviewed or authored by DEUP1 gene expression (9961986)