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Details on Person DEUP1 (Deuterosome assembly protein 1) is a key component of...

Class:IdSummation:9961975
_displayNameDEUP1 (Deuterosome assembly protein 1) is a key component of...
_timestamp2026-05-08 19:03:03
created[InstanceEdit:9961976] Rothfels, Karen, 2025-07-29
modified[InstanceEdit:9962106] Rothfels, Karen, 2025-07-31
[InstanceEdit:9962308] Rothfels, Karen, 2025-08-03
[InstanceEdit:9988570] Rothfels, Karen, 2026-05-08
[InstanceEdit:9988640] Rothfels, Karen, 2026-05-08
textDEUP1 (Deuterosome assembly protein 1) is a key component of the deuterosome, cytosolic doughnut-shaped structures that are the sites for deuterosome-dependent centriole amplification during multiciliated cell (MCC) development (Zhao et al, 2013; Klos Dehring et al, 2013; reviewed in Tang, 2013; Arbi et al, 2018; Shahid and Singh, 2018; Lyu et al, 2024). Expression of DEUP1 is positively regulated by the MCIDAS:E2F4/5:TFDP1 complex although direct binding to the DEUP1 genomic region has not been demonstrated (Ma et al, 2014; Mori et al, 2017; Zhou et al, 2020; Lu et al, 2019). Despite the role of deuterosomes in centriole amplification, massive centriole amplification occurs and functional motile cilia form even when deuterosomes are entirely absent (Mercey et al, 2019). In this case, centriole formation occurs through the centriole-dependent pathway or within the pericentriolar material (Mercey et al, 2019; reviewed in Arbi et al, 2018).
(summation)[BlackBoxEvent:9961986] DEUP1 gene expression [Homo sapiens]
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