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Details on Person NAD+ translocates from the cytosol to the nucleoplasm

Class:Id	BlackBoxEvent:9961806
_displayName	NAD+ translocates from the cytosol to the nucleoplasm
_timestamp	2026-03-23 17:42:23
authored	[InstanceEdit:9961815] May, Bruce, 2025-07-26
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:9961817] May, Bruce, 2025-07-27
edited	[InstanceEdit:9961815] May, Bruce, 2025-07-26
inferredFrom	[Reaction:9982340] NAD+ translocates from the cytosol to the nucleoplasm [Mus musculus]
input	[SimpleEntity:29360] NAD+ [cytosol]
internalReviewed	[InstanceEdit:9985656] Gillespie, Marc E, 2026-03-23
isChimeric	FALSE
modified	[InstanceEdit:9961896] May, Bruce, 2025-07-28 [InstanceEdit:9962276] May, Bruce, 2025-08-03 [InstanceEdit:9982369] May, Bruce, 2026-02-17 [InstanceEdit:9985658] May, Bruce, 2026-03-23
name	NAD+ translocates from the cytosol to the nucleoplasm
output	[SimpleEntity:427523] NAD+ [nucleoplasm]
precedingEvent	[Reaction:197271] NADSYN1 hexamer amidates NAAD to NAD+ [Homo sapiens] [Reaction:197235] NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD [Homo sapiens] [Reaction:8939959] NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ [Homo sapiens] [Reaction:8869633] NMRK1 phosphorylates NR to yield NMN [Homo sapiens] [Reaction:8869627] NMRK2 phosphorylates NR to yield NMN [Homo sapiens] [Reaction:9961787] NAMPT transfers 5-phosphoribose from 5-phosphoribosyl-1-pyrophosphate (PRPP) to nicotinamide (NAM) , yielding nicotinamide mononucleotide (NMN) and pyrophosphate (PPi) [Homo sapiens]
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9961840] R-HSA-9961806.1
summation	[Summation:9961886] NAD+ freely diffuses through the nuclear pore (inferred from...
(hasEvent)	[Pathway:9958957] NAD+ and Sirtuins regulate the circadian clock [Homo sapiens]
(precedingEvent)	[Reaction:9859970] SIRT1 deacetylates Ac-K538,p-S90-BMAL1 in SIRT1:p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:NAMPT gene [Homo sapiens] [Reaction:9860205] SIRT1 deacetylates Ac-K538,p-S90-BMAL1 in SIRT1:Ac-K538,p-S90-BMAL1:CLOCK:PER2 gene [Homo sapiens] [Reaction:9958983] SIRT1 deacetylates Ac-K680-PER2 [Homo sapiens] [Reaction:9960046] SIRT1 deacetylates Ac-13K-PPARGC1 in Ac-13K-PPARGC1A:SIRT1:RORA:BMAL1 gene [Homo sapiens] [Reaction:9960053] SIRT1 deacetylates Ac-K16-Histone H4 and Ac-K9,K14-Histone H3 at the PER2 locus [Homo sapiens] [Reaction:9960066] SIRT6 deacetylates Ac-K-PER2 [Homo sapiens] [Reaction:9961788] SIRT1 deacetylates Ac-K9,K14-Histone H3 and Ac-K16-Histone H4 in SIRT1:p-S90-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:Nucleosome with H3K9acK14ac and H4K16ac:NAMPT gene [Homo sapiens] [Reaction:9961807] SIRT1 deacetylates Ac-K9,K14-Histone H3 and Ac-K16-Histone H4 in p-S90-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:Nucleosome with H3K9acK14ac and H4K16ac:SIRT1 gene [Homo sapiens] [Reaction:9961820] SIRT1 deacetylates Ac-K538,p-S90-BMAL1 in SIRT1:p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:Nucleosome with H3K9ac and H4K16ac:SIRT1 gene [Homo sapiens]
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No pathways have been reviewed or authored by NAD+ translocates from the cytosol to the nucleoplasm (9961806)