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Details on Person NAMPT transfers 5-phosphoribose from 5-phosphoribosyl-1-pyrophosphate (PRPP) to nicotinamide (NAM) , yielding nicotinamide mononucleotide (NMN) and pyrophosphate (PPi)

Class:Id	Reaction:9961787
_displayName	NAMPT transfers 5-phosphoribose from 5-phosphoribosyl-1-pyrophosphate (PRPP) to nicotinamide (NAM) , yielding nicotinamide mononucleotide (NMN) and pyrophosphate (PPi)
_timestamp	2026-03-23 17:42:36
authored	[InstanceEdit:9961815] May, Bruce, 2025-07-26
catalystActivity	[CatalystActivity:197240] nicotinamide phosphoribosyltransferase activity of NAMPT [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9961817] May, Bruce, 2025-07-27
crossReference	[DatabaseIdentifier:9961812] RHEA:16149
edited	[InstanceEdit:9961815] May, Bruce, 2025-07-26
input	[SimpleEntity:197277] NAM [cytosol] [SimpleEntity:73566] PRPP [cytosol] [SimpleEntity:70106] H+ [cytosol]
internalReviewed	[InstanceEdit:9985656] Gillespie, Marc E, 2026-03-23
isChimeric	FALSE
literatureReference	[LiteratureReference:9982326] A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT [LiteratureReference:9982356] Structure and reaction mechanism of human nicotinamide phosphoribosyltransferase [LiteratureReference:9982337] The NAMPT enzyme employs a switch that directly senses AMP/ATP and regulates cellular responses to energy stress
modified	[InstanceEdit:9961896] May, Bruce, 2025-07-28 [InstanceEdit:9982369] May, Bruce, 2026-02-17 [InstanceEdit:9984533] May, Bruce, 2026-03-10 [InstanceEdit:9985658] May, Bruce, 2026-03-23
name	NAMPT transfers 5-phosphoribose from 5-phosphoribosyl-1-pyrophosphate (PRPP) to nicotinamide (NAM) , yielding nicotinamide mononucleotide (NMN) and pyrophosphate (PPi)
output	[SimpleEntity:8869353] NMN [cytosol] [SimpleEntity:111294] PPi [cytosol]
precedingEvent	[BlackBoxEvent:9961792] p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:Nucleosome with H3K9acK14 and H4K16ac:NAMPT gene positively regulates expression of NAMPT [Homo sapiens] [Reaction:9961796] CLOCK acetylates BMAL1 in p-S90-BMAL1:p-T451,T461,S440,S441-CLOCK:Nucleosome:NAMPT gene [Homo sapiens] [Reaction:9961803] CLOCK acetylates Histone H3 and Histone H4 in p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:Nucleosome:NAMPT gene [Homo sapiens]
regulatedBy	[NegativeRegulation:71497] Negative regulation by 'adenosine 5'-monophosphate [cytosol]'
regulationReference	[RegulationReference:9984532] Negative regulation by 'adenosine 5'-monophosphate [cytosol]' The NAMPT enzyme employs a switch that directly senses AMP/ATP and regulates cellular responses to energy stress
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9961823] R-HSA-9961787.1
structureModified	[InstanceEdit:9984533] May, Bruce, 2026-03-10
summation	[Summation:9961887] NAMPT (also known as Visfatin and PBEF) catalyzes the conden...
(hasEvent)	[Pathway:9958957] NAD+ and Sirtuins regulate the circadian clock [Homo sapiens]
(precedingEvent)	[Reaction:8939959] NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+ [Homo sapiens]
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No pathways have been reviewed or authored by NAMPT transfers 5-phosphoribose from 5-phosphoribosyl-1-pyrophosphate (PRPP) to nicotinamide (NAM) , yielding nicotinamide mononucleotide (NMN) and pyrophosphate (PPi) (9961787)