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Details on Person ATP1A:ATP1B1:FXYD3 exchanges 3Na+ for 2K+

Class:Id	Reaction:9961387
_displayName	ATP1A:ATP1B1:FXYD3 exchanges 3Na+ for 2K+
_timestamp	2025-09-25 08:24:26
authored	[InstanceEdit:9961677] Stephan, Ralf, 2025-07-10
catalystActivity	[CatalystActivity:9961491] P-type sodium:potassium-exchanging transporter activity of ATP1A:ATP1B1:FXYD3 [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9961392] Stephan, Ralf, 2025-07-25
input	[SimpleEntity:74126] K+ [extracellular region] [SimpleEntity:74126] K+ [extracellular region] [SimpleEntity:83910] Na+ [cytosol] [SimpleEntity:83910] Na+ [cytosol] [SimpleEntity:83910] Na+ [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:29356] H2O [cytosol]
internalReviewed	[InstanceEdit:9967044] D'Eustachio, Peter, 2025-09-25
isChimeric	FALSE
literatureReference	[LiteratureReference:9961362] Na⁺/K⁺-ATPase: More than an Electrogenic Pump [LiteratureReference:9961539] Cryo-EM structures of recombinant human sodium-potassium pump determined in three different states [LiteratureReference:9961643] Crystal structures of Na⁺ ,K⁺ -ATPase reveal the mechanism that converts the K⁺ -bound form to Na⁺ -bound form and opens and closes the cytoplasmic gate [LiteratureReference:9961685] Expression of alpha- and beta-subunits and activity of Na+K+ ATPase in pig thyroid cells in primary culture: modulation by thyrotropin and thyroid hormones [LiteratureReference:9961647] Tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta 1 (TGF-beta 1) inhibit the expression and activity of Na+/K(+)-ATPase in FRTL-5 rat thyroid cells [LiteratureReference:9961497] Structural and functional properties of two human FXYD3 (Mat-8) isoforms
modified	[InstanceEdit:9966171] Stephan, Ralf, 2025-09-11 [InstanceEdit:9966179] Stephan, Ralf, 2025-09-11 [InstanceEdit:9967043] Stephan, Ralf, 2025-09-25
name	ATP1A:ATP1B1:FXYD3 exchanges 3Na+ for 2K+
output	[SimpleEntity:29804] K+ [cytosol] [SimpleEntity:29804] K+ [cytosol] [SimpleEntity:74113] Na+ [extracellular region] [SimpleEntity:74113] Na+ [extracellular region] [SimpleEntity:74113] Na+ [extracellular region] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29372] Pi [cytosol]
precedingEvent	[Reaction:9961696] AKAP9:KCNQ1:KCNE2 exports K+ [Homo sapiens] [Reaction:9961387] ATP1A:ATP1B1:FXYD3 exchanges 3Na+ for 2K+ [Homo sapiens] [Reaction:9961873] SLC5A5 imports I-, 2Na+ [Homo sapiens] [Reaction:9961387] ATP1A:ATP1B1:FXYD3 exchanges 3Na+ for 2K+ [Homo sapiens] [Reaction:9961427] ANO1 dimer exports I- to follicular lumen [Homo sapiens]
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9961731] R-HSA-9961387.1
summation	[Summation:9961382] Na/K-ATPase (NKA) complex pumps 3 Na+ ions to extracellular ...
(hasEvent)	[Pathway:9961485] Regulation of thyrocyte membrane potential [Homo sapiens]
(precedingEvent)	[Reaction:9961696] AKAP9:KCNQ1:KCNE2 exports K+ [Homo sapiens] [Reaction:9961873] SLC5A5 imports I-, 2Na+ [Homo sapiens]
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No pathways have been reviewed or authored by ATP1A:ATP1B1:FXYD3 exchanges 3Na+ for 2K+ (9961387)