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Details on Person CLOCK in the BMAL1:CLOCK heterodimer acetylates BMAL1 on lys...

Class:IdSummation:9961142
_displayNameCLOCK in the BMAL1:CLOCK heterodimer acetylates BMAL1 on lys...
_timestamp2026-03-23 16:59:45
created[InstanceEdit:9961132] May, Bruce, 2025-07-21
literatureReference[LiteratureReference:9961117] Effect of Resveratrol, a SIRT1 Activator, on the Interactions of the CLOCK/BMAL1 Complex
[LiteratureReference:3697951] CLOCK-mediated acetylation of BMAL1 controls circadian function
[LiteratureReference:9859956] The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control
[LiteratureReference:1368959] Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1
modified[InstanceEdit:9961274] May, Bruce, 2025-07-22
[InstanceEdit:9982446] May, Bruce, 2026-02-17
[InstanceEdit:9982788] May, Bruce, 2026-02-19
[InstanceEdit:9985652] May, Bruce, 2026-03-23
textCLOCK in the BMAL1:CLOCK heterodimer acetylates BMAL1 on lysine-538 (inferred from mouse homologs in Hirayama et al. 2007); SIRT1 deacetylates BMAL1 in the BMAL1:CLOCK heterodimer bound to the promoter of the NAMPT gene (inferred from mouse homologs in Nakahata et al. 2008, 2009), causing a narrower phase and decreased amplitude of expression of NAMPT (Park et al. 2014, inferred from mouse Dbp expression in Nakahata 2008, 2009). NAMPT catalyzes the rate-limiting step of the synthesis of NAD+, a coenzyme used as a substrate by SIRT1. Thus BMAL1:CLOCK and SIRT1 form a regulatory loop via NAD+.
(summation)[Reaction:9859970] SIRT1 deacetylates Ac-K538,p-S90-BMAL1 in SIRT1:p-S90,Ac-K538-BMAL1:p-T451,T461,S440,S441,S446-CLOCK:NAMPT gene [Homo sapiens]
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