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Details on Person FOXJ1 gene expression

Class:Id	BlackBoxEvent:9960942
_displayName	FOXJ1 gene expression
_doRelease	TRUE
_timestamp	2026-05-08 19:12:56
authored	[InstanceEdit:9962119] Rothfels, Karen, 2025-07-31
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9960941] Rothfels, Karen, 2025-07-17
edited	[InstanceEdit:9962258] Rothfels, Karen, 2025-07-31
input	[EntityWithAccessionedSequence:9960918] FOXJ1 gene [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9962310] Orlic-Milacic, Marija, 2025-08-03
isChimeric	FALSE
literatureReference	[LiteratureReference:9960886] De Novo Mutations in FOXJ1 Result in a Motile Ciliopathy with Hydrocephalus and Randomization of Left/Right Body Asymmetry [LiteratureReference:9960894] The forkhead protein Foxj1 specifies node-like cilia in Xenopus and zebrafish embryos [LiteratureReference:9960884] Forkhead transcription factor Fd3F cooperates with Rfx to regulate a gene expression program for mechanosensory cilia specialization [LiteratureReference:9960912] FoxJ1-dependent gene expression is required for differentiation of radial glia into ependymal cells and a subset of astrocytes in the postnatal brain [LiteratureReference:9960874] Foxj1 transcription factors are master regulators of the motile ciliogenic program [LiteratureReference:9945697] Non-oncogenic roles of TAp73: from multiciliogenesis to metabolism [LiteratureReference:9960682] Controlling centriole numbers: Geminin family members as master regulators of centriole amplification and multiciliogenesis [LiteratureReference:9960693] Transcriptional regulation of multiciliated cell differentiation [LiteratureReference:9988635] Role of f-box factor foxj1 in differentiation of ciliated airway epithelial cells [LiteratureReference:9961019] RFX3 governs growth and beating efficiency of motile cilia in mouse and controls the expression of genes involved in human ciliopathies [LiteratureReference:9961010] Rfx2 Stabilizes Foxj1 Binding at Chromatin Loops to Enable Multiciliated Cell Gene Expression [LiteratureReference:9962083] Identification of Important Effector Proteins in the FOXJ1 Transcriptional Network Associated With Ciliogenesis and Ciliary Function [LiteratureReference:9961034] RFX3 modulation of FOXJ1 regulation of cilia genes in the human airway epithelium [LiteratureReference:9960704] GEMC1 is a critical regulator of multiciliated cell differentiation [LiteratureReference:9960729] GemC1 controls multiciliogenesis in the airway epithelium [LiteratureReference:9960338] Mcidas mutant mice reveal a two-step process for the specification and differentiation of multiciliated cells in mammals [LiteratureReference:9945675] TAp73 is a central transcriptional regulator of airway multiciliogenesis [LiteratureReference:9960691] p73 Is Required for Multiciliogenesis and Regulates the Foxj1-Associated Gene Network [LiteratureReference:9945663] MCIDAS mutations result in a mucociliary clearance disorder with reduced generation of multiple motile cilia [LiteratureReference:9960341] Multicilin drives centriole biogenesis via E2f proteins [LiteratureReference:9961072] Myb promotes centriole amplification and later steps of the multiciliogenesis program [LiteratureReference:9960683] Mcidas and GemC1 are key regulators for the generation of multiciliated ependymal cells in the adult neurogenic niche
modified	[InstanceEdit:9961092] Rothfels, Karen, 2025-07-18 [InstanceEdit:9962108] Rothfels, Karen, 2025-07-31 [InstanceEdit:9962257] Rothfels, Karen, 2025-08-01 [InstanceEdit:9962260] Rothfels, Karen, 2025-08-01 [InstanceEdit:9962312] Rothfels, Karen, 2025-08-03 [InstanceEdit:9988586] Rothfels, Karen, 2026-05-08 [InstanceEdit:9988640] Rothfels, Karen, 2026-05-08 [InstanceEdit:9988643] Rothfels, Karen, 2026-05-08
name	FOXJ1 gene expression
output	[EntityWithAccessionedSequence:9960917] FOXJ1 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9960947] TP73 tetramer binds FOXJ1 gene [Homo sapiens] [BlackBoxEvent:9960747] MCIDAS- and GMNC-dependent TP73 gene expression [Homo sapiens] [Reaction:9960945] GMNC dimer:E2F5,E2F4:TFDP1 bind FOXJ1 promoter [Homo sapiens] [Reaction:9960750] GMNC dimer binds E2F4, E2F5 and TFDP1 [Homo sapiens] [BlackBoxEvent:9961082] TP73-dependent MYB gene expression [Homo sapiens] [Reaction:9961078] TP73 tetramer binds MYB gene [Homo sapiens]
regulatedBy	[NegativeGeneExpressionRegulation:9960761] Negative gene expression regulation by 'GMNN [nucleoplasm]' [PositiveGeneExpressionRegulation:9960937] Positive gene expression regulation by 'FOXJ1 gene:TP73 tetramer [nucleoplasm]' [PositiveGeneExpressionRegulation:9960935] Positive gene expression regulation by 'FOXJ1 gene:GMNC dimer:E2F5,E2F4:TFDP1 [nucleoplasm]' [PositiveGeneExpressionRegulation:9961088] Positive gene expression regulation by 'MYB [nucleoplasm]'
regulationReference	[RegulationReference:9960745] Negative gene expression regulation by 'GMNN [nucleoplasm]' GEMC1 is a critical regulator of multiciliated cell differentiation [RegulationReference:9960940] Positive gene expression regulation by 'FOXJ1 gene:TP73 tetramer [nucleoplasm]' TAp73 is a central transcriptional regulator of airway multiciliogenesis [RegulationReference:9960939] Positive gene expression regulation by 'FOXJ gene:GMNC dimer:E2F5,E2F4:TFDP1 [nucleoplasm]' GemC1 controls multiciliogenesis in the airway epithelium [RegulationReference:9961086] Positive gene expression regulation by 'MYB gene:TP73 tetramer [nucleoplasm]' Myb promotes centriole amplification and later steps of the multiciliogenesis program
releaseDate	2026-06-17
reviewed	[InstanceEdit:9988641] Dutcher, Susan K, 2026-05-08 [InstanceEdit:9988584] Rayamajhi, Dheeraj, 2026-05-08 [InstanceEdit:9988583] Roy, Sudipto, 2026-05-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9960952] R-HSA-9960942.1
structureModified	[InstanceEdit:9961092] Rothfels, Karen, 2025-07-18
summation	[Summation:9960869] FOXJ1 is a critical transcriptional regulator of multiciliog...
(hasEvent)	[Pathway:9945556] Transcriptional regulation of multiciliogenesis [Homo sapiens]
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No pathways have been reviewed or authored by FOXJ1 gene expression (9960942)