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Details on Person GMNC dimerizes

Class:IdReaction:9960755
_displayNameGMNC dimerizes
_doReleaseTRUE
_timestamp2026-05-08 19:13:07
authored[InstanceEdit:9962119] Rothfels, Karen, 2025-07-31
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9960753] Rothfels, Karen, 2025-07-16
edited[InstanceEdit:9962258] Rothfels, Karen, 2025-07-31
input[EntityWithAccessionedSequence:9960622] GMNC [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:9960622] GMNC [nucleoplasm] [Homo sapiens]
internalReviewed[InstanceEdit:9962310] Orlic-Milacic, Marija, 2025-08-03
isChimericFALSE
literatureReference[LiteratureReference:9960732] GEMC1 is a TopBP1-interacting protein required for chromosomal DNA replication
[LiteratureReference:9960696] Idas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progression
[LiteratureReference:9960673] The Geminin and Idas coiled coils preferentially form a heterodimer that inhibits Geminin function in DNA replication licensing
[LiteratureReference:9960714] The structure of the GemC1 coiled coil and its interaction with the Geminin family of coiled-coil proteins
[LiteratureReference:9960693] Transcriptional regulation of multiciliated cell differentiation
[LiteratureReference:9960341] Multicilin drives centriole biogenesis via E2f proteins
[LiteratureReference:9960704] GEMC1 is a critical regulator of multiciliated cell differentiation
[LiteratureReference:9960695] GemC1 governs multiciliogenesis through direct interaction with and transcriptional regulation of p73
[LiteratureReference:9960682] Controlling centriole numbers: Geminin family members as master regulators of centriole amplification and multiciliogenesis
modified[InstanceEdit:9962260] Rothfels, Karen, 2025-08-01
[InstanceEdit:9962312] Rothfels, Karen, 2025-08-03
[InstanceEdit:9988586] Rothfels, Karen, 2026-05-08
[InstanceEdit:9988643] Rothfels, Karen, 2026-05-08
nameGMNC dimerizes
output[Complex:9960644] GMNC dimer [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate2026-06-17
reviewed[InstanceEdit:9988641] Dutcher, Susan K, 2026-05-08
[InstanceEdit:9988584] Rayamajhi, Dheeraj, 2026-05-08
[InstanceEdit:9988583] Roy, Sudipto, 2026-05-08
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9960774] R-HSA-9960755.1
summation[Summation:9960615] GMNC dimerizes in a manner that depends on its coiled-coil r...
(hasEvent)[Pathway:9945556] Transcriptional regulation of multiciliogenesis [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9945716] GRHL2-dependent MCIDAS expression [Homo sapiens]
[Reaction:9960750] GMNC dimer binds E2F4, E2F5 and TFDP1 [Homo sapiens]
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